Intermittent and directly observed chemotherapy: the sensible therapeutic option in the treatment of tuberculosis

Wilkinson, D. (1997) Intermittent and directly observed chemotherapy: the sensible therapeutic option in the treatment of tuberculosis. Bailliere's Clinical Infectious Diseases, 4 1: 97-105.

Author Wilkinson, D.
Title Intermittent and directly observed chemotherapy: the sensible therapeutic option in the treatment of tuberculosis
Journal name Bailliere's Clinical Infectious Diseases   Check publisher's open access policy
ISSN 1071-6564
Publication date 1997-03
Sub-type Article (original research)
Volume 4
Issue 1
Start page 97
End page 105
Total pages 9
Place of publication London ; Sydney
Publisher Baillière Tindall
Language eng
Subject 1103 Clinical Sciences
1108 Medical Microbiology
1117 Public Health and Health Services
Abstract Intermittent chemotherapy for tuberculosis-treatment given two or three times each week-is as effective as treatment given every day. Specifically, treatment given three times each week (without a phase of daily therapy) is as effective as treatment given daily. If treatment is given twice weekly, cure rates are equivalent to those achieved when a daily phase is given, and recent evidence suggests that a daily phase is not necessary. Directly observed therapy has been shown to be a highly effective strategy in resource-poor settings and by achieving high completion rates. In combination, directly observed, and intermittent therapy is shown to be highly cost-effective. In the HIV era, with a much increased tuberculosis case-load, hospitalization for 2 months to ensure adherence may no longer be possible. Intermittent and directly observed chemotherapy is indeed the sensible therapeutic option in the treatment of tuberculosis, especially when treatment is delivered in the community in resource-poor settings.
Keyword Tuberculosis
Directly Observed Therapy
Intermittent Chemotherapy
Adherence
Pulmonary Tuberculosis
South-Africa
HIV
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 07 Sep 2010, 13:05:03 EST