High incidence of early anaphylactoid reaction to SAIMR polyvalent snake antivenom

Moran, Neil F., Newman, William J., Theakston, R. David G., Warrell, David A. and Wilkinson, David (1998) High incidence of early anaphylactoid reaction to SAIMR polyvalent snake antivenom. Transactions of the Royal Society of Tropical Medicine and Hygiene, 92 1: 69-70. doi:10.1016/S0035-9203(98)90959-2


Author Moran, Neil F.
Newman, William J.
Theakston, R. David G.
Warrell, David A.
Wilkinson, David
Title High incidence of early anaphylactoid reaction to SAIMR polyvalent snake antivenom
Journal name Transactions of the Royal Society of Tropical Medicine and Hygiene   Check publisher's open access policy
ISSN 0035-9203
Publication date 1998-01-01
Sub-type Article (original research)
DOI 10.1016/S0035-9203(98)90959-2
Volume 92
Issue 1
Start page 69
End page 70
Total pages 2
Place of publication London, England
Publisher Elsevier
Language eng
Subject 1103 Clinical Sciences
1108 Medical Microbiology
1117 Public Health and Health Services
Abstract During a prospective study of 147 patients with snakebite presenting to a rural South African hospital, 13 of 17 patients (76%) treated with South African Institute for Medical Research (SAIMR) polyvalent antivenom experienced potentially severe early (anaphylactoid) reactions. The most common reaction was generalized urticaria (12; 71%), but 3 cases of angio-oedema (18%), 2 of bronchospasm (12%), and 2 of hypotension (12%) were also observed. Reactions were controlled with adrenaline, antihistamines, and resuscitation. All patients fully recovered from envenoming although the full dose of antivenom was not given to most. Indications for the use of this antivenom should be reconsidered and patients should be given antivenom in a high care setting if possible. Use of antivenom by lay people outside hospital should be discouraged and antivenom manufacturing processes could usefully be reviewed.
Keyword Snakebite
Antivenom
Anaphylactoid Reaction
South Africa
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 07 Sep 2010, 23:02:46 EST