The X-chromosome and susceptibility to ankylosing spondylitis

Hoyle, Emma, Laval, Steven H., Calin, Andrei, Wordsworth, B. Paul and Brown, Matthew A. (2000) The X-chromosome and susceptibility to ankylosing spondylitis. Arthritis and Rheumatism, 43 6: 1353-1355. doi:10.1002/1529-0131(200006)43:6<1353::AID-ANR19>3.0.CO;2-B

Author Hoyle, Emma
Laval, Steven H.
Calin, Andrei
Wordsworth, B. Paul
Brown, Matthew A.
Title The X-chromosome and susceptibility to ankylosing spondylitis
Journal name Arthritis and Rheumatism   Check publisher's open access policy
ISSN 0004-3591
Publication date 2000-06
Sub-type Article (original research)
DOI 10.1002/1529-0131(200006)43:6<1353::AID-ANR19>3.0.CO;2-B
Volume 43
Issue 6
Start page 1353
End page 1355
Total pages 3
Place of publication Hoboken. N.J., U.S.A.
Publisher John Wiley & Sons
Language eng
Subject C1
0604 Genetics
Formatted abstract
Ankylosing spondylitis (AS) affects 0.25-1.0% of the population, and its etiology is incompletely understood. Susceptibility to this highly familial disease (λ(s) = 58) is primarily genetically determined. There is a significant sex bias in AS, and there are differences in recurrence risk to the offspring of affected mothers and fathers, suggesting that there may be an X-linked recessive effect. We undertook an X- chromosome linkage study to determine any contribution of the X-chromosome to AS susceptibility.

A linkage study of the X-chromosome using 234 affected sibling pairs was performed to investigate this hypothesis.

No linkage of the X-chromosome with susceptibility to AS was found. Model- free multipoint linkage analysis strongly excluded any significant genetic contribution (λ ≥1.5) to AS susceptibility encoded on the X-chromosome (logarithm of odds [LOD] <-2.0). Smaller genetic effects (A ≥1.3) were also found to be unlikely (LOD <-1.0).

The sex bias in AS is not explained by X-chromosome-encoded genetic effects. The disease model best explaining the sex bias in occurrence and transmission of AS is a polygenic model with a higher susceptibility threshold in females.
Keyword Sex-ratio
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
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Created: Tue, 07 Sep 2010, 10:02:44 EST