A linkage study across the T cell receptor A and T cell receptor B loci in families with rheumatoid arthritis

Hall, F. C., Brown, M. A., Weeks, D. E., Walsh, S., Nicod, A., Butcher, S., Andrews, L. J. and Wordsworth, B. P. (1997) A linkage study across the T cell receptor A and T cell receptor B loci in families with rheumatoid arthritis. Arthritis and Rheumatism, 40 10: 1798-1802. doi:10.1002/art.1780401011


Author Hall, F. C.
Brown, M. A.
Weeks, D. E.
Walsh, S.
Nicod, A.
Butcher, S.
Andrews, L. J.
Wordsworth, B. P.
Title A linkage study across the T cell receptor A and T cell receptor B loci in families with rheumatoid arthritis
Journal name Arthritis and Rheumatism   Check publisher's open access policy
ISSN 0004-3591
1529-0131
Publication date 1997-10
Sub-type Article (original research)
DOI 10.1002/art.1780401011
Volume 40
Issue 10
Start page 1798
End page 1802
Total pages 5
Place of publication Hoboken. N.J., U.S.A.
Publisher John Wiley & Sons
Language eng
Subject C1
0604 Genetics
110322 Rheumatology and Arthritis
Formatted abstract
Objective.
To examine whether the T cell receptor (TCR) A or TCRB loci exhibit linkage with disease in multiplex rheumatoid arthritis (RA) families.

Methods.
A linkage study was performed in 184 RA families from the UK Arthritis and Rheumatism Council Repository, each containing at least 1 affected sibpair. The microsatellites D14S50, TCRA, and D14S64 spanning the TCRA locus and D7S509, Vβ6.7, and D7S688 spanning the TCRB locus were used as DNA markers. The subjects were genotyped using a semiautomated polymerase chain reaction-based method. Two-point and multipoint linkage analyses were performed.

Results.
Nonparametric single-marker likelihood odds (LOD) scores were 0.49 (P = 0.07) for D14S50, 0.65 (P = 0.04) for TCRA, 0.07 (P = 0.29) for D14S64, 0.01 (P = 0.43) for D7S509, 0.0 (P = 0.50) for Vβ6.7, and 0.0 (P = 0.50) for D7S688. By multipoint analysis, there was no evidence of linkage at TCRB (LOD score 0), and the maximum LOD score at the TCRA locus was 0.37 (at D14S50). The presence of a susceptibility locus (LOD score < -2.0) was excluded, with lambda ≤ 1.8 at TCRA and ≤1.4 at TCRB.

Conclusion.
These linkage studies provide no significant evidence of a major germline-encoded TCRA or TCRB component of susceptibility to RA.
Keyword Collagen-induced Arthritis
Susceptibility
Classification
Disequilibrium
Polymorphism
Association
Traits
Genes
Map
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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