The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis

Brown, M. A., Rudwaleit, M., Pile, K. D., Kennedy, L. G., Shatford, J., Amos, C. I., Siminovitch, K., Rubin, L., Calin, A. and Wordsworth, B. P. (1998) The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis. British Journal of Rheumatology, 37 4: 454-458. doi:10.1093/rheumatology/37.4.454


Author Brown, M. A.
Rudwaleit, M.
Pile, K. D.
Kennedy, L. G.
Shatford, J.
Amos, C. I.
Siminovitch, K.
Rubin, L.
Calin, A.
Wordsworth, B. P.
Title The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis
Journal name British Journal of Rheumatology   Check publisher's open access policy
ISSN 0263-7103
1462-0332
Publication date 1998-04
Sub-type Article (original research)
DOI 10.1093/rheumatology/37.4.454
Volume 37
Issue 4
Start page 454
End page 458
Total pages 5
Place of publication London, England
Publisher Oxford University Press for the British Association for Rheumatology
Language eng
Subject 0604 Genetics
110322 Rheumatology and Arthritis
Abstract The role of germline polymorphisms of the T-cell receptor A/D and B loci in susceptibility to ankylosing spondylitis was investigated by linkage studies using microsatellite markers in 215 affected sibling pairs. The presence of a significant susceptibility gene (lambda ≤ 1.6) at the TCRA/D locus was excluded (LOD score < -2.0). At the TCRB locus, there was weak evidence of the presence of a susceptibility gene (P = 0.01, LOD score 1.1). Further family studies will be required to determine whether this is a true or false-positive finding. It is unlikely that either the TCRA/D or TCRB loci contain genes responsible for more than a moderate proportion of the non-MHC genetic susceptibility to ankylosing spondylitis.
Keyword T-cell receptor
ankylosing spondylitis
spondyloarthritis
genetics
linkage
microsatellite
polymorphism
Juvenile Rheumatoid-Arthritis
Complex Traits
Reactive Arthritis
Genetic Dissection
Dna Polymorphisms
Alpha-chain
Linkage
Restriction
Sequence
Disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Tue, 07 Sep 2010, 10:01:38 EST