HLA class I associations of ankylosing spondylitis in the white population in the united Kingdom

Brown, M. A., Pile, K. D., Kennedy, L. G., Calin, A., Darke, C., Bell, J., Wordsworth, B. P. and Cornelis, F. (1996) HLA class I associations of ankylosing spondylitis in the white population in the united Kingdom. Annals of the Rheumatic Diseases, 55 4: 268-270. doi:10.1136/ard.55.4.268


Author Brown, M. A.
Pile, K. D.
Kennedy, L. G.
Calin, A.
Darke, C.
Bell, J.
Wordsworth, B. P.
Cornelis, F.
Title HLA class I associations of ankylosing spondylitis in the white population in the united Kingdom
Journal name Annals of the Rheumatic Diseases   Check publisher's open access policy
ISSN 0003-4967
Publication date 1996-04
Sub-type Article (original research)
DOI 10.1136/ard.55.4.268
Volume 55
Issue 4
Start page 268
End page 270
Total pages 3
Place of publication London, England
Publisher British Medical Association
Language eng
Subject 0604 Genetics
110322 Rheumatology and Arthritis
Formatted abstract
Objective -
To investigate the HLA class I associations of ankylosing spondylitis (AS) in the white population, with particular reference to HLA-B27 subtypes.

Methods -
HLA-B27 and -B60 typing was performed in 284 white patients with AS. Allele frequencies of HLA-B27 and HLA-B60 from 5926 white bone marrow donors were used for comparison. HLA-B27 subtyping was performed by single strand conformation polymorphism (SSCP) in all HLA-B27 positive AS patients, and 154 HLA-B27 positive ethnically matched blood donors.

Results -
The strong association of HLA-B27 and AS was confirmed (odds ratio (OR) 171, 95% confidence interval (CI) 135 to 218; p < 10-99). The association of HLA-B60 with AS was confirmed in HLA-B27 positive cases (OR 3.6, 95% CI 2.1 to 6.3; p < 5 x 10-5), and a similar association was demonstrated in HLA-B27 negative AS (OR 3.5, 95% CI 1.1 to 11.4; p < 0.05). No significant difference was observed in the frequencies of HLA-B27 allelic subtypes in patients and controls (HLA-B*2702, three of 172 patients v five of 154 controls; HLA-B*2705, 169 of 172 patients v 147 of 154 controls; HkA-B*2708, none of 172 patients v two of 154 controls), and no novel HLA-B27 alleles were detected.

Conclusion -

HLA-B27 and -B60 are associated with susceptibility to AS, but differences in BLA-B27 subtype do not affect susceptibility to AS in this white population.
Keyword Polymorphism Analysis
Hla-b27 Subtypes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Tue, 07 Sep 2010, 10:00:50 EST