High antibody levels to P. gingivalis in cardiovascular disease

Bohnstedt, S., Cullinan, M. P., Ford, P. J., Palmer, J. E., Leishman, S. J., Westerman, B., Marshall, R. I., West, M. J. and Seymour, G. J. (2010) High antibody levels to P. gingivalis in cardiovascular disease. Journal of Dental Research, 89 9: 938-942. doi:10.1177/0022034510370817

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Author Bohnstedt, S.
Cullinan, M. P.
Ford, P. J.
Palmer, J. E.
Leishman, S. J.
Westerman, B.
Marshall, R. I.
West, M. J.
Seymour, G. J.
Title High antibody levels to P. gingivalis in cardiovascular disease
Formatted title
High antibody levels to P. gingivalis in cardiovascular disease
Journal name Journal of Dental Research   Check publisher's open access policy
ISSN 0022-0345
Publication date 2010-09
Sub-type Article (original research)
DOI 10.1177/0022034510370817
Volume 89
Issue 9
Start page 938
End page 942
Total pages 5
Editor William V. Giannobile
Place of publication Thousand Oaks, CA, U.S.A.
Publisher Sage Publications
Collection year 2011
Language eng
Formatted abstract
Recent evidence suggests that strain variation in the serum IgG response to Porphyromonas gingivalis occurs in periodontal disease and cardiovascular disease (CVD). This study aimed to test the hypothesis that different P. gingivalis strains would elicit different levels of IgG, depending on a patient’s cardiovascular (CV) and periodontal health. For CVD patients, serum antibody levels increased significantly with increasing numbers of deep pockets for all strains of P. gingivalis, except W50 (p < 0.001). We used a two-way analysis of variance to examine differences in antibody responses across several CV and periodontal groups simultaneously. There was a significant interaction effect (p < 0.05) between periodontal status and CV status for antibody levels to ATCC33277, UQD605, and Su63. This study shows variation in strain type with respect to serum IgG response in several CV and periodontal categories, providing further support for the role of the immune response to P. gingivalis in the relationship between periodontal disease and CVD.
© International & American Associations for Dental Research.
Keyword Periodontal disease
Cardiovascular disease
Serum antibodies
Porphyromonas gingivalis
Strain variation
Risk adjustment
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
ERA 2012 Admin Only
School of Dentistry Publications
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 17 times in Scopus Article | Citations
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Created: Sun, 05 Sep 2010, 00:05:01 EST