Synthetic neovibsanes and their ability to induce neuronal differentiation in PC12 cells

Chen, Apj, Muller, CC, Cooper, HM and Williams, CM (2010) Synthetic neovibsanes and their ability to induce neuronal differentiation in PC12 cells. Tetrahedron, 66 34: 6842-6850. doi:10.1016/j.tet.2010.06.056


Author Chen, Apj
Muller, CC
Cooper, HM
Williams, CM
Title Synthetic neovibsanes and their ability to induce neuronal differentiation in PC12 cells
Journal name Tetrahedron   Check publisher's open access policy
ISSN 0040-4020
1464-5416
Publication date 2010-08
Sub-type Article (original research)
DOI 10.1016/j.tet.2010.06.056
Volume 66
Issue 34
Start page 6842
End page 6850
Total pages 9
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2011
Language eng
Formatted abstract
A series of neovibsanin A and B derivatives and lower homologues were synthesized to study their neurotrophic ability with PC12 cells. 4,5-Bis-epi-neovibsanin A displayed prominent ability to induce neurite outgrowth compared to control cultures. Herein we describe the total synthesis of 4,5-bis-epi-neovibsanin A and B as well as comparing the biological activity of several neovibsane derivatives. © 2010 Elsevier Ltd. All rights reserved.
Keyword Neovibsanin A
Neovibsanin B
Natural product
Neurotrophic activity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Official 2011 Collection
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 05 Sep 2010, 00:00:35 EST