Four published articles are submitted as a thesis for the degree of Doctor of Medicine in the University of Queensland.
The theme of the thesis, that childhood plumbism was responsible for the high incidence of chronic renal disease in Queensland, is developed in the first article, "The Aetiology of Chronic Nephritis in Queensland". The other articles present in detail with relevant historical information, and discuss critically, the three main lines of evidence used in the argument. In addition to establishing the theme for the first time the thesis has a wider significance. It reopens the question of the relation between lead and renal disease.
In the early part of the present century, plumbism was widely held to be a cause of chronic kidney disease. In recent years, for a number of reasons discussed in the thesis, many authorities have refused to accept this relation. The thesis shows lead to be a causal agent, and provides a firm basis for the use of the lead content of bone in investigating the aetiology of chronic renal disease.