Pancreatic acinar cell: New insights into the control of secretion

Low, Jiun T., Shukla, Alka and Thorn, Peter (2010) Pancreatic acinar cell: New insights into the control of secretion. International Journal of Biochemistry and Cell Biology, 42 10: 1586-1589. doi:10.1016/j.biocel.2010.07.006


Author Low, Jiun T.
Shukla, Alka
Thorn, Peter
Title Pancreatic acinar cell: New insights into the control of secretion
Journal name International Journal of Biochemistry and Cell Biology   Check publisher's open access policy
ISSN 1357-2725
1878-5875
Publication date 2010-10
Sub-type Article (original research)
DOI 10.1016/j.biocel.2010.07.006
Volume 42
Issue 10
Start page 1586
End page 1589
Total pages 4
Editor Dr Geoffrey J Laurent
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2011
Language eng
Subject C1
920106 Endocrine Organs and Diseases (excl. Diabetes)
060104 Cell Metabolism
Abstract Pancreatic acinar cells secrete fluid and digestive enzymes. Both types of secretion are activated by a rise in intracellular calcium but how the stimulus-secretion cascade actually regulates secretory output is not well understood. It has long been known that the calcium response of acinar cells to physiological stimulation is complex. Dependent on the type and concentration of agonist, it consists of either local or global calcium increases as well as spreading waves of calcium across the cell. In the past it has been speculated that these different calcium signals drive different secretory responses. Now, recent employment of two-photon microscopy has enabled the simultaneous recording of both enzyme secretion and calcium signals and is beginning to resolve this issue. The data shows that local calcium responses exclusively drive fluid secretion. Where-as, global calcium responses drive both fluid and enzyme secretion. This differential control of secretory output is likely central to controlling the physiological responses of pancreatic acinar cells. © 2010 Elsevier Ltd. All rights reserved.
Keyword Secretion
Pancreas
Epithelial
Calcium
Exocytosis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Biomedical Sciences Publications
 
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Created: Mon, 30 Aug 2010, 14:16:05 EST by Bacsweet Kaur on behalf of School of Biomedical Sciences