Aortic stiffness, but not central or brachial blood pressures, predict physical quality of life

Wright, L, Gilroy, D, Stowasser, M and Sharman, JE (2010). Aortic stiffness, but not central or brachial blood pressures, predict physical quality of life. In: Hypertension. Abstracts from the 31st Annual Scientific Meeting of the High Blood Pressure Research Council of Australia. HBPRCA 2009 ASM: 31st Annual Scientific Meeting of the High Blood Pressure Research Council of Australia, Sydney, NSW, Australia, (1512-1512). 1-3 December 2009. doi:10.1161/HYP.0b013e3181df4279


Author Wright, L
Gilroy, D
Stowasser, M
Sharman, JE
Title of paper Aortic stiffness, but not central or brachial blood pressures, predict physical quality of life
Conference name HBPRCA 2009 ASM: 31st Annual Scientific Meeting of the High Blood Pressure Research Council of Australia
Conference location Sydney, NSW, Australia
Conference dates 1-3 December 2009
Proceedings title Hypertension. Abstracts from the 31st Annual Scientific Meeting of the High Blood Pressure Research Council of Australia   Check publisher's open access policy
Journal name Hypertension   Check publisher's open access policy
Place of Publication Baltimore, MD, U.S.A.
Publisher Lippincott Williams & Wilkins for the American Heart Association
Publication Year 2010
Year available 2009
Sub-type Published abstract
DOI 10.1161/HYP.0b013e3181df4279
ISSN 0194-911X
1524-4563
0073-425X
Volume 55
Issue 6
Start page 1512
End page 1512
Total pages 1
Language eng
Formatted Abstract/Summary
Unless severe and uncontrolled, hypertension is commonly asymptomatic. However, some studies suggest that lower brachial blood pressure (BP) in patients with uncomplicated hypertension may improve quality of life (QOL). The relation between central BP and QOL has never been assessed, but may be relevant because large differences in central systolic BP (SBP) can occur between individuals with similar brachial SBP. This discrepancy between central and brachial SBP is mostly attributed to individual variation in large artery stiffness. We sought to determine the relation between QOL, BP (brachial and central) and large artery stiffness in 104 patients receiving therapy for uncomplicated essential hypertension (aged 63±8 years, 53% male) who were free from a history of cardiovascular or renal disease. The SF-36 health survey was used to quantify QOL. Brachial BP was assessed in the clinic (whilst seated and standing), at home (7 day average) and by 24 hour ambulatory monitoring (24ABPM). Clinic central BP and aortic pulse wave velocity (PWV) (for arterial stiffness) were estimated by applanation tonometry. Neither brachial nor central BP’s were associated with QOL measures (P<0.05 for all). However, physical functioning scores significantly declined across tertiles of aortic PWV (tertile 1; 89±14, tertile 2; 76±22, tertile 3; 76±25) even after correcting for age, gender, clinic brachial SBP and 24ABPM SBP (ANCOVA P<0.028). On multiple regression analysis, aortic PWV (but no BP measure) independently correlated with physical functioning (β=−0.26; P<0.012), but only accounted for 6% of the variance in this QOL variable. We conclude that physical well being is negatively associated with large central artery stiffness, which provides further evidence that interventions to reduce arterial stiffness may improve patient outcomes. Furthermore, central BP appears to offer no additional information beyond brachial BP regarding QOL. Whether this finding will be supported by the use of a hypertension-specific QOL survey needs to be assessed.
Subjects 1103 Clinical Sciences
Q-Index Code EX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published June 1, 2010. Published as Abstract 095.

Document type: Conference Paper
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Created: Sun, 29 Aug 2010, 00:06:03 EST