Cellular and molecular mechanisms of bone remodeling

Raggatt, Liza J. and Partridge, Nicola C. (2010) Cellular and molecular mechanisms of bone remodeling. Journal of Biological Chemistry, 285 33: 25103-25108. doi:10.1074/jbc.R109.041087

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Author Raggatt, Liza J.
Partridge, Nicola C.
Title Cellular and molecular mechanisms of bone remodeling
Journal name Journal of Biological Chemistry   Check publisher's open access policy
ISSN 0021-9258
1083-351X
Publication date 2010-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1074/jbc.R109.041087
Open Access Status File (Publisher version)
Volume 285
Issue 33
Start page 25103
End page 25108
Total pages 6
Place of publication Bethesda, MD USA
Publisher American Society for Biochemistry and Molecular Biology
Collection year 2011
Language eng
Formatted abstract
Physiological bone remodeling is a highly coordinated process responsible for bone resorption and formation and is necessary to repair damaged bone and to maintain mineral homeostasis. In addition to the traditional bone cells (osteoclasts, osteoblasts, and osteocytes) that are necessary for bone remodeling, several immunecells have also been implicated in bone disease. This minireview discusses physiological bone remodeling, outlining the traditional bone biology dogma in light of emerging osteoimmunology data. Specifically discussed in detail are the cellular and molecular mechanisms of bone remodeling, including events that orchestrate the five sequential phases of bone remodeling: activation, resorption, reversal, formation, and termination.
© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.
Keyword In-vivo
Parathyroid-hormone
Terminal Differentiation
Osteoprotegerin Ligand
Tissue Macrophages
Key Regulator
T-cells
Expression
Osteoclasts
Resorption
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes First Published on May 25, 2010

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2011 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 213 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 253 times in Scopus Article | Citations
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Created: Sun, 29 Aug 2010, 00:03:53 EST