Acaricidal Activity of Eugenol Based Compounds against Scabies Mites

Pasay, Cielo, Mounsey, Kate, Stevenson, Graeme, Davis, Rohan, Arlian, Larry, Morgan, Marjorie, Vyszenski-Moher, DiAnn, Andrews, Kathy and McCarthy, James (2010) Acaricidal Activity of Eugenol Based Compounds against Scabies Mites. PLoS One, 5 8: e12079-1-e12079-9. doi:10.1371/journal.pone.0012079

Author Pasay, Cielo
Mounsey, Kate
Stevenson, Graeme
Davis, Rohan
Arlian, Larry
Morgan, Marjorie
Vyszenski-Moher, DiAnn
Andrews, Kathy
McCarthy, James
Title Acaricidal Activity of Eugenol Based Compounds against Scabies Mites
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2010-08
Sub-type Article (original research)
DOI 10.1371/journal.pone.0012079
Open Access Status DOI
Volume 5
Issue 8
Start page e12079-1
End page e12079-9
Total pages 9
Place of publication San Francisco, CA, U.S.A.
Publisher Public Library of Science
Collection year 2011
Language eng
Formatted abstract

Human scabies is a debilitating skin disease caused by the “itch mite” Sarcoptes scabiei. Ordinary scabies is commonly treated with topical creams such as permethrin, while crusted scabies is treated with topical creams in combination with oral ivermectin. Recent reports of acaricide tolerance in scabies endemic communities in Northern Australia have prompted efforts to better understand resistance mechanisms and to identify potential new acaricides. In this study, we screened three essential oils and four pure compounds based on eugenol for acaricidal properties.

Methodology/Principal Findings

Contact bioassays were performed using live permethrin-sensitive S. scabiei var suis mites harvested from pigs and permethrin-resistant S. scabiei var canis mites harvested from rabbits. Results of bioassays showed that clove oil was highly toxic against scabies mites. Nutmeg oil had moderate toxicity and ylang ylang oil was the least toxic. Eugenol, a major component of clove oil and its analogues –acetyleugenol and isoeugenol, demonstrated levels of toxicity comparable to benzyl benzoate, the positive control acaricide, killing mites within an hour of contact.


The acaricidal properties demonstrated by eugenol and its analogues show promise as leads for future development of alternative topical acaricides to treat scabies.

Copyright: © 2010 Pasay et al.

Keyword Dermatophagoides-pteronyssinus acari
Bud oil compounds
Chemical composition
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number: e12079, pp. 1-9.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2011 Collection
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 31 times in Scopus Article | Citations
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Created: Sun, 29 Aug 2010, 00:01:17 EST