An event-related fMRI study of phonological verbal working memory in schizophrenia

Kim, Jejoong, Matthews, Natasha L. and Park, Sohee (2010) An event-related fMRI study of phonological verbal working memory in schizophrenia. PloS One, 5 8: e12068-1-e12068-9. doi:10.1371/journal.pone.0012068

Author Kim, Jejoong
Matthews, Natasha L.
Park, Sohee
Title An event-related fMRI study of phonological verbal working memory in schizophrenia
Journal name PloS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2010-08
Sub-type Article (original research)
DOI 10.1371/journal.pone.0012068
Open Access Status DOI
Volume 5
Issue 8
Start page e12068-1
End page e12068-9
Total pages 9
Place of publication San Francisco, CA, U.S.A.
Publisher Public Library of Science
Collection year 2011
Language eng
Formatted abstract
Background: While much is known about the role of prefrontal cortex (PFC) in working memory (WM) deficits of schizophrenia, the nature of the relationship between cognitive components of WM and brain activation patterns remains unclear. We aimed to elucidate the neural correlates of the maintenance component of verbal WM by examining correct and error trials with event-related fMRI. Methodology/Findings: Twelve schizophrenia patients (SZ) and thirteen healthy control participants (CO) performed a phonological delayed-matching-to-sample-task in which a memory set of three nonsense words was presented, followed by a 6-seconds delay after which a probe nonsense word appeared. Participants decided whether the probe matched one of the targets, and rated the confidence of their decision. Blood-oxygen-level-dependent (BOLD) activity during WM maintenance was analyzed in relation to performance (correct/error) and confidence ratings. Frontal and parietal regions exhibited increased activation on correct trials for both groups. Correct and error trials were further segregated into true memory, false memory, guess, and true error trials. True memory trials were associated with increased bilateral activation of frontal and parietal regions in both groups but only CO showed deactivation in PFC. There was very little maintenancerelated cortical activity during guess trials. False memory was associated with increased left frontal and parietal activation in both groups. Conclusion: These findings suggest that a wider network of frontal and parietal regions support WM maintenance in correct trials compared with error trials in both groups. Furthermore, a more extensive and dynamic pattern of recruitment of the frontal and parietal networks for true memory was observed in healthy controls compared with schizophrenia patients. These results underscore the value of parsing the sources of memory errors in fMRI studies because of the non-linear nature of the brain-behavior relationship, and suggest that group comparisons need to be interpreted in more specific behavioral contexts.
© 2010 Kim et al.
Keyword Dorsolateral prefrontal cortex
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article e12068

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Sun, 29 Aug 2010, 00:01:15 EST