Persistent pulmonary hypertension and abnormal prostaglandin E levels in preterm infants after maternal treatment with naproxen

Wilkinson, A.R., Aynsley-Green, A. and Mitchell, M.D. (1979) Persistent pulmonary hypertension and abnormal prostaglandin E levels in preterm infants after maternal treatment with naproxen. Archives of Disease in Childhood, 54 12: 942-945. doi:10.1136/adc.54.12.942


Author Wilkinson, A.R.
Aynsley-Green, A.
Mitchell, M.D.
Title Persistent pulmonary hypertension and abnormal prostaglandin E levels in preterm infants after maternal treatment with naproxen
Journal name Archives of Disease in Childhood   Check publisher's open access policy
ISSN 0003-9888
1468-2052
Publication date 1979-12
Sub-type Article (original research)
DOI 10.1136/adc.54.12.942
Volume 54
Issue 12
Start page 942
End page 945
Total pages 4
Place of publication London, England
Publisher BMJ Publishing Group
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract Twins and a singleton were born at 30 weeks' gestation although naproxen (d-2 (6' methoxy-2-naphthyl) propionic acid) had been given to the mothers in an attempt to delay parturition. Inhibition of prostaglandin synthesis was shown by very low plasma concentrations of prostaglandin E and the ductus arteriosus remained closed despite signs of pulmonary hypertension with severe hypoxaemia. Abnormalities in blood clotting, renal function, and bilirubin metabolism were also found and one infant died. Further studies of the benefits and risks of the inhibition of prostaglandin synthesis are required before this treatment of preterm labour is accepted.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 13:20:16 EST