Prostanoids in rabbit aqueous humor: Effect of laser photocoagulation of the iris

Weinreb, R.N., Weaver, D. and Mitchell, M.D. (1985) Prostanoids in rabbit aqueous humor: Effect of laser photocoagulation of the iris. Investigative Ophthalmology & Visual Science, 26 8: 1087-1092.

Author Weinreb, R.N.
Weaver, D.
Mitchell, M.D.
Title Prostanoids in rabbit aqueous humor: Effect of laser photocoagulation of the iris
Journal name Investigative Ophthalmology & Visual Science   Check publisher's open access policy
ISSN 0146-0404
Publication date 1985
Sub-type Article (original research)
Volume 26
Issue 8
Start page 1087
End page 1092
Total pages 6
Place of publication Rockville, MD, U.S.A.
Publisher Association for Research in Vision and Ophthalmology
Language eng
Subject 1103 Clinical Sciences
1113 Ophthalmology and Optometry
Formatted abstract
The authors measured concentrations of prostanoids (prostaglandin-like substances) in aqueous humor from normal pigmented rabbit eyes and from those subjected to argon laser photocoagulation of the iris. The predominant prostanoids quantitatively were prostaglandin E2 (PGE2), PGF(2α), and PGD2 with minor amounts of 6-keto-PGF(1α) and thromboxane B2. In all cases, concentrations of prostanoids in laser-treated eyes were substantially greater than those in normal eyes. This finding was particularly striking in the case of PGE2 which increased 60-fold from 87 pg/ml to 5.5 ng/ml after irradiation. Concentrations of prostanoids following photocoagulation were related to the number of administered laser lesions and prostanoid release was associated with an initial hypertensive response and disruption of the blood-aqueous barrier.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 13:20:12 EST