Modulation of prostanoid synthesis by antimicrobials

Strickland, D.M., Saeed, S.A. and Mitchell, M.D. (1983) Modulation of prostanoid synthesis by antimicrobials. Biochemical Pharmacology, 32 17: 2625-2627. doi:10.1016/0006-2952(83)90036-9


Author Strickland, D.M.
Saeed, S.A.
Mitchell, M.D.
Title Modulation of prostanoid synthesis by antimicrobials
Journal name Biochemical Pharmacology   Check publisher's open access policy
ISSN 0006-2952
Publication date 1983
Sub-type Other
DOI 10.1016/0006-2952(83)90036-9
Volume 32
Issue 17
Start page 2625
End page 2627
Total pages 3
Place of publication New York, N.Y. U.S.A.
Publisher Elsevier
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Formatted abstract
In summary, the results of this study are indicative that antibiotics can modify the synthesis of several prostanoids. A mixture of antimicrobials that is commonly used in culture media caused a decrease in the production of PGE2 and TXB2 (but not PGF(2α)). Testing of the individual component drugs produced results suggestive that the inhibitory activity resides in the streptomycin, penicillin and amphotericin being without effect in the concentrations tested. The prostaglandin synthase inhibitory effect of the streptomycin at concentrations used in tissue cultures is probably not of sufficient magnitude by itself to alter significantly prostaglandin production rates. It has been reported, however, that aminoglycoside antibiotics can also inhibit phospholipase C activity.
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Other
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 13:18:45 EST