The modulation of prostaglandin synthesis by peritoneal fluids

Strickland, D.M., Bombard, A.T., Trabal, J.F. and Mitchell, M.D. (1990) The modulation of prostaglandin synthesis by peritoneal fluids. Prostaglandins, 40 3: 331-335. doi:10.1016/0090-6980(90)90019-R

Author Strickland, D.M.
Bombard, A.T.
Trabal, J.F.
Mitchell, M.D.
Title The modulation of prostaglandin synthesis by peritoneal fluids
Journal name Prostaglandins   Check publisher's open access policy
ISSN 0090-6980
Publication date 1990-09
Sub-type Article (original research)
DOI 10.1016/0090-6980(90)90019-R
Volume 40
Issue 3
Start page 331
End page 335
Total pages 5
Place of publication Stoneham, Ma., U.S.A.
Publisher Butterworths
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Formatted abstract
Biological fluids from several sources (e.g. blood, fetal urine, amniotic fluid) have been shown to contain factors that modulate prostaglandin (PG) synthesis. In this study, we investigated the possibility that peritoneal fluid contains substances that may regulate PG synthesis. Peritoneal fluids were obtained from women undergoing diagnostic laparoscopy for infertility. Fluids from women without evident pelvic pathology were incubated with prostaglandin synthase prepared from bull seminal vesicles in the presence of excess arachidonic acid, and the production of PGE2, PGF(2α), and 6-keto-PGF(1α) was quantified by specific radioimmunoassay. The untreated fluids inhibited potently the synthesis of PGE2 but such inhibitory activity was not extractable by chloroform:methanol. An ultrafiltrate of the fluid containing molecules smaller than 10,000 Daltons stimulated PGF(2α) synthesis but this activity was also lost after extraction. The extracted fluid did, however, stimulate the synthesis of prostacyclin (as reflected by 6-keto-PGF(1α)).
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Created: Thu, 26 Aug 2010, 13:18:00 EST