Endothelin in the urine of children with the hemolytic uremic syndrome

Siegler, Richard L., Edwin, Samuel S., Christofferson, Ryan D. and Mitchell, Murray D. (1991) Endothelin in the urine of children with the hemolytic uremic syndrome. Pediatrics, 88 5: 1063-1066.

Author Siegler, Richard L.
Edwin, Samuel S.
Christofferson, Ryan D.
Mitchell, Murray D.
Title Endothelin in the urine of children with the hemolytic uremic syndrome
Journal name Pediatrics   Check publisher's open access policy
ISSN 0031-4005
Publication date 1991-11
Sub-type Other
Volume 88
Issue 5
Start page 1063
End page 1066
Total pages 4
Place of publication Washington, DC, U.S.A.
Publisher American Academy of Pediatrics
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract The pathogenic cascade leading to acute renal failure and hypertension in classic childhood hemolytic uremic syndrome (HUS) presumably is initiated by injury to the renal vascular endothelial cells. Multisystem involvement often occurs, apparently as a consequence of widespread endothelial cell perturbation. There is evidence that endothelial cell injury can be caused by circulating Shiga-like toxins (verotoxins) produced by certain diarrhea-producing enteric organisms (eg, Escherichia coli 0157:H7). Platelet and coagulation cascade activation probably occur secondarily with subsequent platelet-fibrin deposition within the renal microvasculature. Kidney biopsy specimens, however, often fail to show structural damage sufficient to account for the severe oliguric renal failure that often occurs in the syndrome.
Keyword Vasoconstrictor Peptide
Relaxing Factor
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Other
Collection: UQ Centre for Clinical Research Publications
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Created: Thu, 26 Aug 2010, 13:16:51 EST