Delayed luteal regression in ewes immunized against oxytocin

Sheldrick, E.L., Mitchell, M.D. and Flint, A.P.F. (1980) Delayed luteal regression in ewes immunized against oxytocin. Journal of Reproduction and Fertility, 59 1: 37-42. doi:10.1530/jrf.0.0590037

Author Sheldrick, E.L.
Mitchell, M.D.
Flint, A.P.F.
Title Delayed luteal regression in ewes immunized against oxytocin
Journal name Journal of Reproduction and Fertility   Check publisher's open access policy
ISSN 0022-4251
Publication date 1980-05
Sub-type Article (original research)
DOI 10.1530/jrf.0.0590037
Volume 59
Issue 1
Start page 37
End page 42
Total pages 6
Place of publication Oxford, England
Publisher Blackwell Scientific Publications
Language eng
Subject 1103 Clinical Sciences
0606 Physiology
Abstract Active immunization of sheep against oxytocin prolonged the luteal phase of the oestrous cycle, as judged by oestrous behaviour and circulating progesterone concentrations. Mean cycle length was extended by 3-7 days. The treatment resulted in a 10-fold increase in circulating oxytocin concentrations. Antisera produced were specific for oxytocin; cross-reactions with vasotocin, arginine vasopressin, and hypothalamic releasing factors were low. Cerebrospinal fluid contained low levels of antibodies directed against oxytocin. This finding supports the hypothesis that the luteolytic action of oestradiol-17β in sheep may be mediated through a stimulatory effect on the endometrial oxytocin receptor concentration.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Created: Thu, 26 Aug 2010, 13:16:47 EST