Cytosolic phospholipase A(2) and 15-hydroxyprostaglandin dehydrogenase mRNA expression in murine uterine and gestational tissues during late pregnancy

Sato, T. A., Gupta, D. K., Keelan, J. A., Marvin, K. W. and Mitchell, M. D. (2001) Cytosolic phospholipase A(2) and 15-hydroxyprostaglandin dehydrogenase mRNA expression in murine uterine and gestational tissues during late pregnancy. Prostaglandins Leukotrienes and Essential Fatty Acids, 64 4-5: 247-251. doi:10.1054/plef.2001.0267


Author Sato, T. A.
Gupta, D. K.
Keelan, J. A.
Marvin, K. W.
Mitchell, M. D.
Title Cytosolic phospholipase A(2) and 15-hydroxyprostaglandin dehydrogenase mRNA expression in murine uterine and gestational tissues during late pregnancy
Journal name Prostaglandins Leukotrienes and Essential Fatty Acids   Check publisher's open access policy
ISSN 0952-3278
1532-2823
Publication date 2001-04
Sub-type Article (original research)
DOI 10.1054/plef.2001.0267
Volume 64
Issue 4-5
Start page 247
End page 251
Total pages 5
Place of publication Edinburgh ; New York
Publisher Churchill Livingstone
Language eng
Subject 0604 Genetics
1114 Paediatrics and Reproductive Medicine
Formatted abstract
We evaluated the changes in mRNA expression of cytosolic phospholipase A2 (cPLA2) and 15-hydroxyprostaglandin dehydrogenase (PGDH) in intrauterine and gestational tissues during mid-late murine pregnancy. Tissues (decidual caps, fetal membranes, and placentae, uterus, and cervix) were collected from pregnant mice at days 12, 14, 16, 18, and 19 (am and pm) of gestation. Total RNAwas isolated and evaluated for cPLA2 and PGDH expression by northern blot analysis normalized to GAPDH expression. Expression of mRNA for cPLA2 increased in the placentae and decidual caps on day 18 and 19 pm, respectively. There was also increased expression for PGDH mRNA in the placenta and fetal membranes at the later stages of pregnancy. The tissue specific differences in expression of cPLA2 and PGDH suggest that changes in enzymatic regulation of PG production and degradation may be crucial for the initiation of labour. © 2001 Harcourt Publishers Ltd.
Keyword Messenger-Ribonucleic-Acid
Fetal Membranes
Human Amnion
Wish Cells
Preterm Labor
Term
Localization
Parturition
Placenta
RNA
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 13:13:36 EST