Inhibition of prostaglandin biosynthesis by human low-density and high-density lipoproteins

Saeed, S. A. and Mitchell, M. D. (1982) Inhibition of prostaglandin biosynthesis by human low-density and high-density lipoproteins. Prostaglandins Leukotrienes and Medicine, 8 3: 185-189. doi:10.1016/0262-1746(82)90041-5


Author Saeed, S. A.
Mitchell, M. D.
Title Inhibition of prostaglandin biosynthesis by human low-density and high-density lipoproteins
Journal name Prostaglandins Leukotrienes and Medicine   Check publisher's open access policy
ISSN 0262-1746
Publication date 1982-03
Sub-type Article (original research)
DOI 10.1016/0262-1746(82)90041-5
Volume 8
Issue 3
Start page 185
End page 189
Total pages 5
Place of publication Edinburgh ; New York
Publisher Churchill Livingstone
Language eng
Subject 0604 Genetics
0601 Biochemistry and Cell Biology
Formatted abstract
The ability of human low-density lipoprotein (LDL) and high-density lipoprotein (HDL) to inhibit the biosynthesis of prostaglandin (PG) E2, F(2α) and prostacyclin from arachidonic acid by bull seminal vesicle (BSV) PG synthase was studied. Both LDL and HDL inhibited the PG synthase activity in BSV microsomes. The greatest inhibitory effect was observed against the biosynthesis of PGE2. These results show an hitherto unrecognised property of human lipoproteins that may mediate some of the biological actions of these substances.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 13:13:07 EST