Amniotic fluid 5-hydroxyeicosatetraenoic acid in preterm labor

Romero, Roberto, Wu, Ying King, Mazor, Moshe, Hobbins, John C. and Mitchell, Murray D. (1988) Amniotic fluid 5-hydroxyeicosatetraenoic acid in preterm labor. Prostaglandins, 36 2: 179-189. doi:10.1016/0090-6980(88)90305-X

Author Romero, Roberto
Wu, Ying King
Mazor, Moshe
Hobbins, John C.
Mitchell, Murray D.
Title Amniotic fluid 5-hydroxyeicosatetraenoic acid in preterm labor
Journal name Prostaglandins   Check publisher's open access policy
ISSN 0090-6980
Publication date 1988-08
Sub-type Article (original research)
DOI 10.1016/0090-6980(88)90305-X
Volume 36
Issue 2
Start page 179
End page 189
Total pages 11
Place of publication Stoneham, Ma., U.S.A.
Publisher Butterworths
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract 5-Hydroxyeicosatetraenoic acid (5-HETE) is an arachidonate lipoxygenase product capable of stimulating human uterine contractility in a dose-dependent manner in vitro. The purpose of this study was to determine if preterm labor is associated with changes in the concentration of this metabolite in amniotic fluid. Amniotic fluid was obtained by transabdominal amniocentesis from three groups of women with preterm labor: group 1 - women without intraamniotic infection who responded to tocolysis (n = 32); group 2 - women without intraamniotic infection who failed to respond to tocolysis (n = 22); and group 3 - women with intraamniotic infection (n = 14). 5-HETE was determined by radioimmunoassay. The median amniotic fluid concentration of 5-HETE in women who responded to tocolysis (median = 1412 pg/ml; range: 111-3547) was significantly lower than in women who delivered despite tocolysis (median = 2052 pg/ml; range: 136-7774) and women with intraamniotic infection (median = 1876 pg/ml; range: 543-7033) [p < 0.05]. No difference in amniotic fluid concentrations of 5-HETE were found between women in groups 2 and 3 (p > 0.05).
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Created: Thu, 26 Aug 2010, 13:12:19 EST