Endotoxin stimulates prostaglandin E2 production by human amnion

Romero, R., Hobbins, J.C. and Mitchell, M.D. (1988) Endotoxin stimulates prostaglandin E2 production by human amnion. Obstetrics and Gynecology, 71 2: 227-228.

Author Romero, R.
Hobbins, J.C.
Mitchell, M.D.
Title Endotoxin stimulates prostaglandin E2 production by human amnion
Formatted title
Endotoxin stimulates prostaglandin E2 production by human amnion
Journal name Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0029-7844
Publication date 1988-02
Sub-type Article (original research)
Volume 71
Issue 2
Start page 227
End page 228
Total pages 2
Place of publication New York, N.Y. U.S.A.
Publisher American College of Obstetricians and Gynecologists
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Formatted abstract
The studies presented in this report were designed to evaluate whether bacterial endotoxin alters the rate of biosynthesis of prostaglandin E2 (PGE2) by human amnion. Amnion cells were established in primary monolayer culture from women undergoing elective cesarean sections. Endotoxin from Escherichia coli and Salmonella typhosa were incubated with amnion cells for 16 hours, and radioimmunoassay was used to measure PGE2 released into the media. Bacterial endotoxin demonstrated a concentration-dependent stimulatory effect on the rate of PGE2 synthesis by amnion cells. These observations suggest a mechanism for the onset of labor associated with intra-amniotic infection.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 13:11:38 EST