Amniotic fluid prostanoid concentrations increase early during the course of spontaneous labor at term

Romero, R., Baumann, P., Gonzalez, R., Gomez, R., Rittenhouse, L., Behnke, E. and Mitchell, M.D. (1994) Amniotic fluid prostanoid concentrations increase early during the course of spontaneous labor at term. American Journal of Obstetrics and Gynecology, 171 6: 1613-1620.

Author Romero, R.
Baumann, P.
Gonzalez, R.
Gomez, R.
Rittenhouse, L.
Behnke, E.
Mitchell, M.D.
Title Amniotic fluid prostanoid concentrations increase early during the course of spontaneous labor at term
Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0002-9378
Publication date 1994-12
Sub-type Article (original research)
Volume 171
Issue 6
Start page 1613
End page 1620
Total pages 8
Place of publication St. Louis, Mo. U.S.A.
Publisher Mosby
Language eng
Subject 0604 Genetics
1114 Paediatrics and Reproductive Medicine
Formatted abstract
Objective:
The purpose of this study was to determine whether amniotic fluid concentrations of prostanoids increase during spontaneous labor at term.

Study design:

Amniotic fluid was retrieved transabdominally from 168 patients in spontaneous labor and from 82 patients not in labor. Prostaglandin E2, prostaglandin F(2α), 13,14-dihydro-15-keto-prostaglandin F(2α), thromboxane B2, and 6-keto-prostaglandin F(1α) concentrations were measured with sensitive and specific radioimmunoassays previously validated for amniotic fluid. Statistical analysis was conducted with Kruskal-Wallis analysis of variance, followed by Dunn's test for multiple comparisons.

Results:
(1) Amniotic fluid concentrations of all prostanoids were significantly higher in patients in early labor (cervical dilatation of ≤3 cm) than in patients not in labor.
(2) The-magnitude of the increase in amniotic fluid prostanoid concentrations during early labor was significantly greater for prostaglandin F(2α) and 13,14-dihydro-15-keto-prostaglandin F(2α) than for prostaglandin E2, thromboxane B2, and 6-keto-prostaglandin F(1α).
(3) Patients in the active phase of labor with cervical dilatations between 4 and 7 cm did not have higher prostanoid concentrations than those in early labor (cervical dilatation of ≤3 cm).
(4) A significant increase in amniotic fluid concentrations of prostaglandin F2α and 13,14-dihydro-15-keto-prostaglandin F(2α) was found in patients with advanced cervical dilatation (8 to 10 cm) in comparison with those in early labor (<3 cm).

Conclusion:
Amniotic fluid prostanoid concentrations increase early during the course of spontaneous labor at term.
Keyword Prostanoids
Prostaglandins
Eicosanoids
Parturition
Term Labor
Human Parturition
Preterm Labor
Pregnancy
Plasma
Sheep
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 13:11:16 EST