Endothelin-1,2 levels are increased in the amniotic fluid of women with preterm labor and microbial invasion of the amniotic cavity

Romero, R., Avila, C., Edwin, S.S. and Mitchell, M.D. (1992) Endothelin-1,2 levels are increased in the amniotic fluid of women with preterm labor and microbial invasion of the amniotic cavity. American Journal of Obstetrics and Gynecology, 166 1: 95-99.

Author Romero, R.
Avila, C.
Edwin, S.S.
Mitchell, M.D.
Title Endothelin-1,2 levels are increased in the amniotic fluid of women with preterm labor and microbial invasion of the amniotic cavity
Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0002-9378
1097-6868
Publication date 1992-01
Sub-type Article (original research)
Volume 166
Issue 1
Start page 95
End page 99
Total pages 5
Place of publication St. Louis, MO, United States
Publisher Mosby
Language eng
Subject 0604 Genetics
1114 Paediatrics and Reproductive Medicine
Abstract The purpose of this study was to determine the effect of gestational age, labor, and microbial invasion of the amniotic cavity on amniotic fluid concentrations of endothelin-1,2. Amniotic fluid was retrieved by amniocentesis from 148 women: patients at term with and without labor, patients with preterm labor with and without intraamniotic infection, and women in the second trimester of pregnancy. Endothelin-1,2 was measured by a sensitive and specific radioimmunoassay. Immunoreactive endothelin-1,2 was detectable in all samples of human amniotic fluid. Advancing gestational age and spontaneous term labor did not result in changes in amniotic fluid concentrations of endothelin-1,2. Women with preterm labor and positive amniotic fluid cultures for microorganisms had higher amniotic fluid concentrations of endothelin-1,2 than did those without microbial invasion of the amniotic cavity (p < 0.05). These results support a role for endothelins in the mechanisms responsible for preterm delivery associated with intraamniotic infection.
Keyword Endothelins
Intra-Amniotic Infection
Preterm Labor
Chorioamnionitis
Smooth-muscle Cells
Vasoconstrictor peptide
Fetal Blood
Interleukin-1
Precursor
Infection
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 13:11:08 EST