ACTH control of steroid secretion from adrenal cells of the developing rhesus monkey (Macaca mulatta)

Roebuck, M.M., Jones, C.T., Robinson, J.S., Mitchell, M.D. and Thorburn, G.D. (1984) ACTH control of steroid secretion from adrenal cells of the developing rhesus monkey (Macaca mulatta). Acta Endocrinologica, 105 4: 545-551.

Author Roebuck, M.M.
Jones, C.T.
Robinson, J.S.
Mitchell, M.D.
Thorburn, G.D.
Title ACTH control of steroid secretion from adrenal cells of the developing rhesus monkey (Macaca mulatta)
Journal name Acta Endocrinologica   Check publisher's open access policy
ISSN 0001-5598
0300-9750
Publication date 1984
Sub-type Article (original research)
Volume 105
Issue 4
Start page 545
End page 551
Total pages 7
Place of publication Copenhagen, Denmark
Publisher Periodica
Language eng
Subject 1103 Clinical Sciences
Abstract Cells from adrenal glands of 140-160 days foetal, neonatal and infant Rhesus monkeys (Macaca mulatta) were prepared, by collagenase digestion and incubated with 10 pg-16 bg/ml ACTH. The production of cortisol, androstenedione, corticosterone, progesterone and prostaglandins was measured. The cortisol production in the 140 day and 160 day foetuses and in the neonatal adrenal cells was comparable. It was 2-fold higher in adrenal cells of 6 month infant monkeys. In all the groups there was an increasing production of cortisol with increasing ACTH concentration, and a response to low physiological concentrations of ACTH. The androstenedione production was significantly greater in the 160 day foetuses than in either those of 140 days or of the neonate which demonstrated a poor response to increasing ACTH concentrations. It responded well to increasing ACTH in adrenal cells from 6 month infant monkeys. Corticosterone output was 1/10th of cortisol with only the 140 day foetuses showing an increase in production with increasing ACTH concentrations. The results demonstrate that cells of the primate foetal adrenal gland are not inherently unresponsive to ACTH stimulation as regards cortisol production, which per kg/μg DNA does not appear to change over the last 25 days before term.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 13:11:04 EST