Artemin stimulates oncogenicity and invasiveness of human endometrial carcinoma cells

Pandey, Vijay, Qian, Peng-Xu, Kang, Jian, Perry, Jo K., Mitchell, Murray D., Yin, Zhinan, Wu, Zheng-Sheng, Liu, Dong-Xu, Zhu, Tao and Lobie, Peter E. (2010) Artemin stimulates oncogenicity and invasiveness of human endometrial carcinoma cells. Endocrinology, 151 3: 909-920. doi:10.1210/en.2009-0979

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Author Pandey, Vijay
Qian, Peng-Xu
Kang, Jian
Perry, Jo K.
Mitchell, Murray D.
Yin, Zhinan
Wu, Zheng-Sheng
Liu, Dong-Xu
Zhu, Tao
Lobie, Peter E.
Title Artemin stimulates oncogenicity and invasiveness of human endometrial carcinoma cells
Journal name Endocrinology   Check publisher's open access policy
ISSN 0013-7227
Publication date 2010-03
Sub-type Article (original research)
DOI 10.1210/en.2009-0979
Volume 151
Issue 3
Start page 909
End page 920
Total pages 12
Place of publication Bethesda, MA, United States
Publisher Endocrine Society
Collection year 2011
Language eng
Subject 0604 Genetics
1103 Clinical Sciences
Abstract Here, we provide evidence for a functional role of artemin (ARTN) in progression of endometrial carcinoma (EC). Increased ARTN protein expression was observed in EC compared with normal endometrial tissue, and ARTN protein expression in EC was significantly associated with higher tumor grade and invasiveness. Forced expression of ARTN in EC cells significantly increased total cell number as a result of enhanced cell cycle progression and cell survival. In addition, forced expression of ARTN significantly enhanced anchorage-independent growth and invasiveness of EC cells. Moreover, forced expression of ARTN increased tumor size in xenograft models and produced highly proliferative, poorly differentiated, and invasive tumors. The ARTN-stimulated increases in oncogenicity and invasion were mediated by increased expression and activity of AKT1. Small interfering RNA-mediated depletion or antibody inhibition of ARTN significantly reduced oncogenicity and invasion of EC cells. Thus, inhibition of ARTN may be considered as a potential therapeutic strategy to retard progression of EC. Copyright © 2010 by The Endocrine Society.
Keyword Signal-regulated Kinase
Human Growth-hormone
Neurotrophic Factor
Rceptor family
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2011 Collection
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 22 times in Scopus Article | Citations
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Created: Thu, 26 Aug 2010, 13:08:49 EST