Actions of endothelin-1 on prostaglandin production by gestational tissues

Mitchell, M.D., Romero, R.J., Lepera, R., Rittenhouse, L. and Edwin, S.S. (1990) Actions of endothelin-1 on prostaglandin production by gestational tissues. Prostaglandins, 40 6: 627-635. doi:10.1016/0090-6980(90)90007-I


Author Mitchell, M.D.
Romero, R.J.
Lepera, R.
Rittenhouse, L.
Edwin, S.S.
Title Actions of endothelin-1 on prostaglandin production by gestational tissues
Journal name Prostaglandins   Check publisher's open access policy
ISSN 0090-6980
Publication date 1990-12
Sub-type Article (original research)
DOI 10.1016/0090-6980(90)90007-I
Volume 40
Issue 6
Start page 627
End page 635
Total pages 9
Place of publication Stoneham, Ma., U.S.A.
Publisher Butterworths
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Formatted abstract
Endothelin-1 (10-11M-10-7M) was incubated with human umbilical vein enthothelial cells and cells derived from amnion and decidua and prostaglandin production was determined. The rates of biosynthesis of 6-keto-prostaglandin F(1α) (6-keto-PGF(1α) and prostaglandin E2 (PGE2) by endothelial cells were increased significantly by treatment with endothelin-1. Amnion cell PGE2 production was reduced significantly by endothelin-1 treatment whereas decidual PGE2 and prostaglandin F(2α) production was unaffected by this treatment. Thus, it is possible that endothelins may play a part in the regulation of uteroplacental hemodynamics and the mechanisms of parturition.
Keyword Smooth-muscle Cells
Vasoconstrictor peptide
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 13:06:30 EST