Prostaglandins and parturition

Mitchell, M.D., Romero, R.J., Edwin, S.S. and Trautman, M.S. (1995). Prostaglandins and parturition. In: Reproduction, Fertility, and Development:. Thorburn International Symposium in Recognition of the Scientific Contributions to Reproductive and Perinatal Physiology of Geoffrey Donald Thorburn, Hamilton Island, Great Barrier Reef, Australia, (623-632). 5-9 August, 1994. doi:10.1071/RD9950623

Author Mitchell, M.D.
Romero, R.J.
Edwin, S.S.
Trautman, M.S.
Title of paper Prostaglandins and parturition
Conference name Thorburn International Symposium in Recognition of the Scientific Contributions to Reproductive and Perinatal Physiology of Geoffrey Donald Thorburn
Conference location Hamilton Island, Great Barrier Reef, Australia
Conference dates 5-9 August, 1994
Proceedings title Reproduction, Fertility, and Development:   Check publisher's open access policy
Journal name Reproduction Fertility and Development   Check publisher's open access policy
Place of Publication East Melbourne, Vic. Australia
Publisher CSIRO in co-operation with the Australian Academy of Science
Publication Year 1995
Sub-type Fully published paper
DOI 10.1071/RD9950623
ISSN 1031-3613
Volume 7
Issue 3
Start page 623
End page 632
Total pages 9
Language eng
Abstract/Summary It seems likely that prostaglandins play a significant part in the mechanisms of parturition both at term and preterm. Concentrations of prostaglandins are increased in the blood, urine and amniotic fluid during labour. There are differences in the concentrations of prostaglandins in amniotic fluid from the forebag and hindbag. Nevertheless, if liquor is sampled only from the hindbag a highly significant increase in prostaglandin concentrations occurs throughout labour. Furthermore, we now have evidence that prostaglandin concentrations in amniotic fluid increase before the onset of labour. Prostaglandins are synthesized by uterine tissues and increased rates of production occur during labour. The amnion, chorion and decidua all contain mRNA for the newly-discovered inducible form of prostaglandin H synthase (PGHS-2) as well as mRNA for the constitutive form (PGHS-1). Using the reverse transcription polymerase chain reaction (RT-PCR) both mRNAs can be detected during late pregnancy whether women are in labour or not. PGHS-2 protein is detected by Western blot analysis in cells derived from all three tissues. There is regulation of PGHS-2 protein amounts by cytokines, phorbol esters and growth factors. For example, in amnion cells interleukin-1 beta induces a rapid increase in PGHS-2 mRNA levels followed by a decrease to undetectable levels within 4 h of treatment; PGHS-2 protein amounts are also elevated by this treatment. Administration of prostaglandins will induce labour and delivery, whereas inhibition of prostaglandin biosynthesis will delay labour and delivery. Hence, increased prostaglandin production is likely to be a key determinant of the onset and progression of the parturient process.
Subjects 1103 Clinical Sciences
1115 Pharmacology and Pharmaceutical Sciences
Keyword Human-Fetal Membranes
G/H Synthase
Endoperoxide Synthase
Uterine Cervix
Cdna Cloning
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
Collection: UQ Centre for Clinical Research Publications
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Citation counts: TR Web of Science Citation Count  Cited 92 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 26 Aug 2010, 13:06:27 EST