Paradoxical stimulation of both lipocortin and prostaglandin production in human amnion cells by dexamethasone

Mitchell, Murray D., Lytton, Fiona D. and Varticovski, Lyuba (1988) Paradoxical stimulation of both lipocortin and prostaglandin production in human amnion cells by dexamethasone. Biochemical and Biophysical Research Communications, 151 1: 137-141. doi:10.1016/0006-291X(88)90569-4


Author Mitchell, Murray D.
Lytton, Fiona D.
Varticovski, Lyuba
Title Paradoxical stimulation of both lipocortin and prostaglandin production in human amnion cells by dexamethasone
Journal name Biochemical and Biophysical Research Communications   Check publisher's open access policy
ISSN 0006-291X
Publication date 1988-02-29
Sub-type Article (original research)
DOI 10.1016/0006-291X(88)90569-4
Volume 151
Issue 1
Start page 137
End page 141
Total pages 5
Place of publication New York, N.Y. U.S.A.
Publisher Academic Press
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract Glucocorticoids inhibit prostaglandin biosynthesis by inducing the formation of lipocortins. In human amnion cells dexamethasone elicited a concentration-dependent increase in prostaglandin production and raised intracellular lipocortin 1 concentrations. Dexamethasone could also potentiate the epidermal growth factor (EGF)-induced stimulation of prostaglandin production. EGF alone or in combination with dexamethasone increased lipocortin 1 formation in amnion cells. Human amnion cells may provide a unique insight into interactions between glucocorticoids, lipocortin and eicosanoid biosynthesis.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 23:05:47 EST