Plasma prostaglandin levels during early neonatal life following term and pre-term delivery

Mitchell, M.D., Lucas, A., Etches, P.C., Brunt, J.D. and Turnbull, A.C. (1978) Plasma prostaglandin levels during early neonatal life following term and pre-term delivery. Prostaglandins, 16 2: 319-326. doi:10.1016/0090-6980(78)90033-3


Author Mitchell, M.D.
Lucas, A.
Etches, P.C.
Brunt, J.D.
Turnbull, A.C.
Title Plasma prostaglandin levels during early neonatal life following term and pre-term delivery
Journal name Prostaglandins   Check publisher's open access policy
ISSN 0090-6980
Publication date 1978-08
Sub-type Article (original research)
DOI 10.1016/0090-6980(78)90033-3
Volume 16
Issue 2
Start page 319
End page 326
Total pages 8
Place of publication Stoneham, Ma., U.S.A.
Publisher Butterworths
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract The concentrations of prostaglandin E (PGE), prostaglandin F (PGF) and 13,14-dihydro-15-oxo-PGF (PGFM) have been measured by sensitivie and specific radioimmunoassays in neonatal plasma after term and pre-term delivery. Blood samples were taken in the term delivery group from the umbilical artery at birth and on the sixth post-natal day and after pre-term delivery at 2-4 days, on the sixth day, at 2-4 weeks and at 5-8 weeks after birth. The levels of prostaglandins circulating during the first month of life were far greater than those found in normal adults. In neonates delivered at term the plasma concentration of PGE was significantly lower six days after delivery compared with the concentration at delivery whereas the concentrations of PGF and PGFM were essentially unchanged. Following pre-term delivery prostaglandin concentrations declined with increasing neonatal age although only levels of PGE at 5-8 weeks of age were within the normal range of adult values. Comparison of prostaglandin levels six days after delivery between neonates born at term and pre-term showed to significant differences. These results suggest that prematurity per se is not associated with marked abnormalities in the ability of the neonate to synthesize or metabolize prostaglandins.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 64 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 42 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 26 Aug 2010, 13:05:37 EST