Evidence for a local control of prostaglandins within the pregnant human uterus

Mitchell, M. D., Keirse, M. J. N. C., Anderson, A. B. M. and Turnbull, A. C. (1977) Evidence for a local control of prostaglandins within the pregnant human uterus. British Journal of Obstetrics and Gynaecology, 84 1: 35-38. doi:10.1111/j.1471-0528.1977.tb12463.x


Author Mitchell, M. D.
Keirse, M. J. N. C.
Anderson, A. B. M.
Turnbull, A. C.
Title Evidence for a local control of prostaglandins within the pregnant human uterus
Journal name British Journal of Obstetrics and Gynaecology   Check publisher's open access policy
ISSN 0306-5456
Publication date 1977-01
Sub-type Article (original research)
DOI 10.1111/j.1471-0528.1977.tb12463.x
Volume 84
Issue 1
Start page 35
End page 38
Total pages 4
Place of publication London, England
Publisher Elsevier
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract Prostaglandin F (PGF) and 13,14-dihydro-15-keto-PGF (PGFM) have been measured in amniotic fluid in late human pregnancy. The method used to obtain amniotic fluid greatly influenced the levels of prstaglandins: fluid obtained by vaginal amniotomy contained significantly higher levels of both PGF and PGFM than samples taken at amniocentesis, reflecting an increase in synthesis and/or release of prostaglandin rather than a decrease in the rate of metabolism. After 36 weeks gestation there was no increase in levels of either PGF or PGFM if samples obtained by amniotomy and amniocentesis were considered separately, although if such samples were considered together a significant increase could be obtained. The apparently rapid change in prostaglandin concentrations in amniotic fluid in response to amniotomy strongly supports a local control of these compounds within the pregnant uterus.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 13:04:53 EST