Cytokine-induced coordinate expression of enzymes of prostaglandin biosynthesis and metabolism: 15-hydroxyprostaglandin dehydrogenase

Mitchell, M. D., Goodwin, V., Mesnage, S. and Keelan, J. A. (2000) Cytokine-induced coordinate expression of enzymes of prostaglandin biosynthesis and metabolism: 15-hydroxyprostaglandin dehydrogenase. Prostaglandins Leukotrienes and Essential Fatty Acids, 62 1: 1-5. doi:10.1054/plef.1999.0117


Author Mitchell, M. D.
Goodwin, V.
Mesnage, S.
Keelan, J. A.
Title Cytokine-induced coordinate expression of enzymes of prostaglandin biosynthesis and metabolism: 15-hydroxyprostaglandin dehydrogenase
Journal name Prostaglandins Leukotrienes and Essential Fatty Acids   Check publisher's open access policy
ISSN 0952-3278
1532-2823
Publication date 2000-01
Sub-type Article (original research)
DOI 10.1054/plef.1999.0117
Volume 62
Issue 1
Start page 1
End page 5
Total pages 5
Place of publication Edinburgh ; New York
Publisher Churchill Livingstone
Language eng
Subject 0604 Genetics
1114 Paediatrics and Reproductive Medicine
Abstract The effects of pro-inflammatory cytokines on 15-hydroxyprostaglandin dehydrogenase (PGDH) expression and prostaglandin (PG) metabolizing activity were investigated in placental tissue. Treatment of trophoblast cells in primary culture with interleukin-1β (IL-1β) or tumour necrosis factor-α (TNF-α) resulted in decreased prostaglandin metabolizing activity. This was assessed both by determining the ratio of production of prostaglandins to their metabolites, and by Northern blot analysis of PGDH mRNA abundance. Dexamethasone had similar inhibitory effect. We hypothesize that proinflammatory cytokines act to enhance prostaglandin actions through coordinated effects on activities of enzymes of both prostaglandin biosynthesis and metabolism, perhaps in concert with effects on receptor function. (C) 2000 Harcourt Publishers Ltd.
Keyword Ribonucleic-Acid Abundance
Endoperoxide-H Synthase-1
Preterm Labor
Fetal Membranes
Messenger-rna
Human Amnion
Wish Cells
Term Labor
Infection
Parturition
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 13:04:08 EST