Rapid increases in plasma prostaglandin concentrations after vaginal examination and amniotomy

Mitchell, M.D., Flint, A.P.F., Bibby, J., Brunt, J., Arnold, J.M., Anderson, A.B.M. and Turnbull, A.C. (1977) Rapid increases in plasma prostaglandin concentrations after vaginal examination and amniotomy. BMJ, 2 6096: 1183-1185. doi:10.1136/bmj.2.6096.1183


Author Mitchell, M.D.
Flint, A.P.F.
Bibby, J.
Brunt, J.
Arnold, J.M.
Anderson, A.B.M.
Turnbull, A.C.
Title Rapid increases in plasma prostaglandin concentrations after vaginal examination and amniotomy
Journal name BMJ   Check publisher's open access policy
ISSN 0959-8146
0959-8138
Publication date 1977-11-05
Sub-type Article (original research)
DOI 10.1136/bmj.2.6096.1183
Open Access Status DOI
Volume 2
Issue 6096
Start page 1183
End page 1185
Total pages 3
Place of publication London, England
Publisher British Medical Association
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract Peripheral plasma concentrations of 13,14-dihydro-15-keto prostaglandin F (PGFM) were measured in three groups of women after the 37th week of pregnancy. Samples were taken before and five minutes after amniotomy, vaginal examination with sweeping of the fetal membranes or vaginal examination without sweeping of the membranes. Each procedure significantly raised the circulating PGFM levels, although amniotomy and vaginal examination with membrane sweep were more potent stimuli than vaginal examination alone. These findings suggest that there is a considerable potential for rapid increases in prostaglandin production during late pregnancy and provide a possible explanation for the fact that amniotomy and vaginal examination with membrane sweep often initiate labour.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 13:03:39 EST