Epidermal growth factor and the regulation of amnion prostaglandin biosynthesis

Mitchell, M.D., Edwin, S.S., Lepera, R. and Lundin-Schiller, S. (1991) Epidermal growth factor and the regulation of amnion prostaglandin biosynthesis. Prostaglandins Leukotrienes and Essential Fatty Acids, 44 1: 57-59. doi:10.1016/0952-3278(91)90145-U


Author Mitchell, M.D.
Edwin, S.S.
Lepera, R.
Lundin-Schiller, S.
Title Epidermal growth factor and the regulation of amnion prostaglandin biosynthesis
Journal name Prostaglandins Leukotrienes and Essential Fatty Acids   Check publisher's open access policy
ISSN 0952-3278
1532-2823
Publication date 1991-09
Sub-type Article (original research)
DOI 10.1016/0952-3278(91)90145-U
Volume 44
Issue 1
Start page 57
End page 59
Total pages 3
Place of publication Edinburgh ; New York
Publisher Churchill Livingstone
Language eng
Subject 0604 Genetics
1114 Paediatrics and Reproductive Medicine
Abstract The production of prostaglandins by amnion is a key factor in the mechanism of human parturition yet the regulation of prostaglandin biosynthesis in amnion is poorly understood. Hence, we have investigated the regulation of epidermal growth factor (EGF) stimulation of prostaglandin biosynthesis in human amnion cells. This stimulatory action is inhibited by cycloheximide or actinomycin D at high concentrations, but enhanced at much lower concentrations of these protein synthesis inhibitors. An amnion-produced prostaglandin inhibitor or immediate early gene action may explain these effects. Pretreatment with phorbol esters (inhibition of protein kinase C activity) reduces basal prostaglandin production and attenuates the stimulatory action of EGF on prostaglandin biosynthesis. Hence, amnion prostaglandin biosynthesis is dependent partly on protein kinase C activity.
Keyword Protein Kinase-C
Human Parturition
Stimulation
Cells
Activators
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 13:03:04 EST