Prostaglandin synthase inhibitory activity in the plasma of rhesus monkeys during late pregnancy: Effect of dexamethasone

Mitchell, Murray D., Brennecke, Shaun P. and Novy, Miles J. (1984) Prostaglandin synthase inhibitory activity in the plasma of rhesus monkeys during late pregnancy: Effect of dexamethasone. Prostaglandins Leukotrienes and Medicine, 14 2: 199-204. doi:10.1016/0262-1746(84)90203-8


Author Mitchell, Murray D.
Brennecke, Shaun P.
Novy, Miles J.
Title Prostaglandin synthase inhibitory activity in the plasma of rhesus monkeys during late pregnancy: Effect of dexamethasone
Journal name Prostaglandins Leukotrienes and Medicine   Check publisher's open access policy
ISSN 0262-1746
Publication date 1984-05-01
Sub-type Article (original research)
DOI 10.1016/0262-1746(84)90203-8
Volume 14
Issue 2
Start page 199
End page 204
Total pages 6
Place of publication Edinburgh ; New York
Publisher Churchill Livingstone
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
0604 Genetics
Abstract Plasma from rhesus monkeys during late pregnancy contained a factor(s) that was inhibitory of prostaglandin synthase activity. There was no consistent trend in the inhibitory activity of plasma obtained between 120 days of gestation and term (approximately 167 days of gestation). Administration of dexamethasone (0.125 to 1.0 mg twice daily) consistently increased inhibitory activity in plasma after an initial treatment period of 5-10 days. Administration of dexamethasone for several weeks is associated with prolongation of gestation in rhesus monkeys. We suggest that the action of dexamethasone, to delay parturition is related, in part, to an enhancement of the activity of a circulating factor(s) that is inhibitory of prostaglandin synthase activity.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 23:02:16 EST