Progesterone withdrawal without parturition

Mitchell, M.D., Brennecke, S.P., Kraemer, D.L. and Webb, R. (1983) Progesterone withdrawal without parturition. European Journal of Obstetrics Gynecology and Reproductive Biology, 15 1: 25-30. doi:10.1016/0028-2243(83)90293-9

Author Mitchell, M.D.
Brennecke, S.P.
Kraemer, D.L.
Webb, R.
Title Progesterone withdrawal without parturition
Journal name European Journal of Obstetrics Gynecology and Reproductive Biology   Check publisher's open access policy
ISSN 0301-2115
Publication date 1983
Sub-type Article (original research)
DOI 10.1016/0028-2243(83)90293-9
Volume 15
Issue 1
Start page 25
End page 30
Total pages 6
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract It has been demonstrated that administration of 100 mg of trilostane (an inhibitor of 3β-hydroxy-steroid dehydrogenase) to late pregnant sheep will rapidly lower circulating levels of progesterone and that delivery ensues. Our intention was to reduce the dose of trilostane in order to separate the latter two sequelae and thereby obtain insight into the relationship between progesterone and prostaglandin biosynthesis. At the dose chosen (10 mg) the treatment did not induce parturition in 4 chronically catheterized sheep during late pregnancy. Circulating progesterone concentrations declined precipitously in all ewes but recovered to near basal values by 24 h after administration of trilostane. Circulating concentrations of 13,14-dihydro-15-keto-prostaglandin F(2α) rose slightly but significantly at 4-5 h after administration of trilostane but never reached values normally associated with labor. Plasma estradiol levels were unchanged by treatment. These results are consistent with the view that progesterone withdrawal must be of a critical magnitude and duration for prostaglandin biosynthesis to be sufficiently stimulated to induce labor in sheep during late gestation.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Created: Thu, 26 Aug 2010, 13:02:13 EST