Current topic: The regulation of placental eicosanoid biosynthesis

Mitchell, M.D. (1991) Current topic: The regulation of placental eicosanoid biosynthesis. Placenta, 12 6: 557-572. doi:10.1016/0143-4004(91)90492-X

Author Mitchell, M.D.
Title Current topic: The regulation of placental eicosanoid biosynthesis
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
Publication date 1991-11
Sub-type Editorial
DOI 10.1016/0143-4004(91)90492-X
Volume 12
Issue 6
Start page 557
End page 572
Total pages 16
Place of publication London, England
Publisher W.B. Saunders
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract Products of arachidonic acid metabolism (eicosanoids, e.g. some prostaglandins and leukotrienes) have important roles in the maintenance of pregnancy, the mechanism(s) of parturition and various diseases of pregnancy such as pregnancy-induced hypertension. The wealth of literature describing these relationships dictates that the present review be focused rather than global in nature. Only studies of human tissues will be discussed despite the limitations in experimental design that are imposed on such studies. Emphasis will be placed on studies of the cyclooxygenase and to a lesser extent lipoxygenase pathways of arachidonic acid metabolism mentioning only briefly the epoxygenase pathway and catabolic pathways. It should also be noted that many eicosanoids are not derived from arachidonic acid and will not be discussed here. The review of literature will not be comprehensive but rather selective in order to focus on specific issues of importance or controversy. In order to develop concepts of regulation I have focused a section on amnion since this tissue has received most attention for such studies. The significance of the products of the pathways described in the physiologic and pathophysiologic events of pregnancy will be described primarily in a section in which I have attempted to delineate those regulatory mechanisms that are considered most significant in, or specific to pregnancy and parturition. Finally, the reader is dirccted to several excellent reviews that concentrate on areas not emphasized in this review (Keirse, 1979; Challis and Patrick, 1980; Mitchell, 1982; Hammarstrom, 1983; Samuelsson and Funk,1989; Smith, 1989; Myatt, 1990).
Keyword Human Amnion Cells
Human-Fetal Membranes
Protein Kinase-C
Platelet-activating Factor
Arachidonic-acid Metabolism
Human Parturition
Prostacyclin Production
Prostaglandin Synthase
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Editorial
Collection: UQ Centre for Clinical Research Publications
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 26 Aug 2010, 13:01:15 EST