The regulation of decidual prostaglandin biosynthesis by growth factors, phorbol esters, and calcium

Mitchell, M.D. (1991) The regulation of decidual prostaglandin biosynthesis by growth factors, phorbol esters, and calcium. Biology of Reproduction, 44 5: 871-874. doi:10.1095/biolreprod44.5.871


Author Mitchell, M.D.
Title The regulation of decidual prostaglandin biosynthesis by growth factors, phorbol esters, and calcium
Journal name Biology of Reproduction   Check publisher's open access policy
ISSN 0006-3363
Publication date 1991-05-01
Sub-type Article (original research)
DOI 10.1095/biolreprod44.5.871
Volume 44
Issue 5
Start page 871
End page 874
Total pages 4
Place of publication Madison, WI, U.S.A.
Publisher Society for the Study of Reproduction
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract The production of prostaglandins by decidua may play a significant part in the mechanisms of human parturition. We have evaluated the regulation of prostaglandin production in human decidual cells in monolayer culture. Both epidermal growth factor and transforming growth factor-alpha induced concentration-related increases in decidual prostaglandin production with significant changes occurring at concentrations of 1 to 10 ng/ml. Two active phorbol esters elicited concentration-related increases in decidual prostaglandin production whereas an inactive phorbol analogue was without effect. The calcium ionophores, ionomycin and A-23187, also stimulated prostaglandin production by human decidual cell cultures. Hence prostaglandin production by human decidua is regulated by hormones and agents in a manner similar to that of other cells including amnion and may play a significant part in the mechanism of parturition.
Keyword Human Amnion Cells
Human Parturition
Uterine Decidua
Potential Role
Stimulation
Metabolism
Pregnancy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 13:01:12 EST