Expression of intercellular adhesion molecule-1 (ICAM-1) in choriodecidua with labour and delivery at term and preterm

Marvin, Keith W., Keelan, Jeffrey A., Sato, Timothy A., Coleman, Matthew A. G., McCowan, Lesley M. E. and Mitchell, Murray D. (1999) Expression of intercellular adhesion molecule-1 (ICAM-1) in choriodecidua with labour and delivery at term and preterm. Reproduction Fertility and Development, 11 4-5: 255-262. doi:10.1071/RD99066


Author Marvin, Keith W.
Keelan, Jeffrey A.
Sato, Timothy A.
Coleman, Matthew A. G.
McCowan, Lesley M. E.
Mitchell, Murray D.
Title Expression of intercellular adhesion molecule-1 (ICAM-1) in choriodecidua with labour and delivery at term and preterm
Journal name Reproduction Fertility and Development   Check publisher's open access policy
ISSN 1031-3613
1448-5990
Publication date 1999
Sub-type Article (original research)
DOI 10.1071/RD99066
Volume 11
Issue 4-5
Start page 255
End page 262
Total pages 8
Place of publication East Melbourne, Vic. Australia
Publisher CSIRO in co-operation with the Australian Academy of Science
Language eng
Subject 1103 Clinical Sciences
1115 Pharmacology and Pharmaceutical Sciences
Abstract To evaluate the association between intercellular adhesion molecule-1 (ICAM-1) in the choriodecidua and preterm labour and delivery, ICAM-1 mRNA abundance was assessed by northern analysis, and protein levels by ELISA, in samples of this tissue after term and preterm delivery. The median ICAM-1 mRNA expression following preterm delivery (PTD) was 4.8 and 3.8 times (P<0.05), respectively, those following elective Caesarean section prior to labour at term (CST) and following vaginal delivery after spontaneous labour at term (SLT). The concentration of ICAM-1 protein in the PTD samples was 2.2 and 3.0 times (P<0.05) those in CST and SLT samples, respectively. The differences between the term groups were not significant. The results were substantially the same when a preterm spontaneous labour (PTL) subgroup, exclusive of deliveries complicated by pre-eclampsia or intrauterine growth restriction, was compared with the term groups. Choriodecidual ICAM-1 mRNA expression, but not ICAM-1 protein concentration, significantly correlated to the degree of leukocyte infiltration of the PTD gestational membranes. Neither correlated significantly to clinical indications of intrauterine or neonatal infection. These findings indicate that ICAM-1 is expressed by the human choriodecidua and that this expression is elevated with preterm labour and delivery, particularly with increased leukocyte infiltration.
Keyword Cell Adhesion Molecules
Gestational Membranes
Inflammation
Intrauterine Infection
Parturition
Premature labour
Intrauterine Growth-retardation
Tumor-necrosis-factor
Amniotic-fluid
Epithelial-cells
Endothelial-cells
Fetal Fibronectin
Birth-weight
Infection
Membranes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 12:59:59 EST