Enhanced expression of intercellular adhesion molecule-1 (ICAM-1) in amnion with term and preterm labour

Marvin, K.W., Keelan, J.A., Sato, T.A., Coleman, M.A.G., McCowan, L.M.E., Miller, H.C. and Mitchell, M.D. (2000) Enhanced expression of intercellular adhesion molecule-1 (ICAM-1) in amnion with term and preterm labour. Placenta, 21 1: 115-121. doi:10.1053/plac.1999.0457

Author Marvin, K.W.
Keelan, J.A.
Sato, T.A.
Coleman, M.A.G.
McCowan, L.M.E.
Miller, H.C.
Mitchell, M.D.
Title Enhanced expression of intercellular adhesion molecule-1 (ICAM-1) in amnion with term and preterm labour
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
Publication date 2000-01
Sub-type Article (original research)
DOI 10.1053/plac.1999.0457
Volume 21
Issue 1
Start page 115
End page 121
Total pages 7
Place of publication London, England
Publisher W.B. Saunders
Language eng
Subject 1103 Clinical Sciences
1115 Pharmacology and Pharmaceutical Sciences
Abstract To evaluate the association between intercellular adhesion molecule-1 (ICAM-1) in the amnion and preterm labour and delivery, we have assessed ICAM-1 mRNA abundance by Northern analysis and protein levels by enzyme-linked immunosorbent assay (ELISA), in samples of this tissue after term and preterm delivery. The median ICAM-1 mRNA expression following preterm delivery (PTD, n = 30) was 24 times greater (P < 0.05) than following elective caesarean section prior to labour at term (CST, n = 14). ICAM-1 expression following vaginal delivery after spontaneous labour at term (SLT, n = 11) was seven times greater than in the CST group (P < 0.05). The concentration of ICAM-1 protein in the PTD samples (n = 31) was four-fold greater than (P < 0.05) in CST (n = 14). It was also three-fold greater than in the SLT (n = 15) samples (P < 0.05). The results were substantially the same when a preterm spontaneous labour group (PTL) (n = 26), exclusive of deliveries complicated by pre-eclampsia (n = 1) or intrauterine growth restriction (n = 3), was compared to the CST and SLT groups. The ICAM-1 mRNA expression did not differ significantly (P = 0.93) between PTL with (n = 12) or without (n = 14) indicators of intrauterine infection. The results were similar when ICAM-1 protein concentrations were compared (P = 0.43) between these two groups. These findings indicate that ICAM-1 is expressed by the human amnion and that this expression is elevated with preterm labour and delivery. (C) 2000 Harcourt Publishers Ltd.
Keyword Intrauterine Growth-retardation
Fetal Fibronectin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Created: Thu, 26 Aug 2010, 12:59:53 EST