Subcellular localization of prostaglandin H synthase-2 in a human amnion cell line: implications for nuclear localized prostaglandin signaling pathways

Marvin, K. W., Eykholt, R. L. and Mitchell, M. D. (2000) Subcellular localization of prostaglandin H synthase-2 in a human amnion cell line: implications for nuclear localized prostaglandin signaling pathways. Prostaglandins Leukotrienes and Essential Fatty Acids, 62 1: 7-11. doi:10.1054/plef.1999.0118


Author Marvin, K. W.
Eykholt, R. L.
Mitchell, M. D.
Title Subcellular localization of prostaglandin H synthase-2 in a human amnion cell line: implications for nuclear localized prostaglandin signaling pathways
Journal name Prostaglandins Leukotrienes and Essential Fatty Acids   Check publisher's open access policy
ISSN 0952-3278
1532-2823
Publication date 2000-01
Sub-type Article (original research)
DOI 10.1054/plef.1999.0118
Volume 62
Issue 1
Start page 7
End page 11
Total pages 5
Place of publication Edinburgh ; New York
Publisher Churchill Livingstone
Language eng
Subject 0604 Genetics
1114 Paediatrics and Reproductive Medicine
Formatted abstract
We have determined that prostaglandin H synthase-2 localises strongly to the nuclear membrane as well as being found in the endoplasmic reticulum in human amnion-derived WISH cells which have been stimulated with interleukin 1β and phorbol ester. This is consistent with findings in cells of non-reproductive origin. There is strong evidence that prostaglandin J2 derivatives, which in other tissues exhibit tumour suppressing, antiproliferative and/or differentiation promoting activities, act through binding of intracellular receptors which then enter the nucleus. In addition, some arachidonic acid derivatives are clearly generated by enzymes at the nuclear envelope and localise to sites in nuclei or bind sites in nuclei. The WISH cell line will make an excellent system for studying these perinuclear intracellular prostanoid signaling mechanisms. (C) 2000 Harcourt Publishers Ltd.
Keyword Basophilic Leukemia-cells
Swiss 3T3 Cells
Messenger-rna
Endoplasmic-reticulum
Arachidonic-acid
Gene Disruption
Ppar-gamma
Expression
Protein
5-lipoxygenase
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 12:59:35 EST