Uterine prostaglandin production in ovine pregnancy: Effects of angiotensin II and indomethacin

Magness, R.R., Rosenfeld, C.R., Faucher, D.J. and Mitchell, M.D. (1992) Uterine prostaglandin production in ovine pregnancy: Effects of angiotensin II and indomethacin. American Journal of Physiology - Heart & Circulatory Physiology, 263 1: H188-H197.

Author Magness, R.R.
Rosenfeld, C.R.
Faucher, D.J.
Mitchell, M.D.
Title Uterine prostaglandin production in ovine pregnancy: Effects of angiotensin II and indomethacin
Journal name American Journal of Physiology - Heart & Circulatory Physiology   Check publisher's open access policy
ISSN 0002-9513
Publication date 1992-07
Sub-type Article (original research)
Volume 263
Issue 1
Start page H188
End page H197
Total pages 10
Place of publication Washington, DC, U.S.A.
Publisher American Physiological Society
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Formatted abstract
The ovine and human uteroplacental vascular beds are more refractory to angiotensin II (ANG II)-induced vasoconstriction than the systemic vasculature. ANG II increases in vitro prostacyclin (PGI2) production by uterine but not omental arteries from pregnant sheep. Thus vasodilator prostaglandins may account for this difference in vascular responsiveness. We measured uterine and systemic eicosanoid production and hemodynamic responses in pregnant sheep before and during intravenous ANG II (1.15 and 11.5 μg/min). ANG II caused dose-related increases in arterial pressure and systemic and uterine vascular resistance (P < 0.05). PGI2 metabolite (6- keto-PGF(1α)) in the uterine vein rose from 166 ± 70 (SE) to 223 ± 114 and 631 ± 323 pg/ml, respectively (P < 0.05), and arterial levels increased from 67 ± 24 to 145 ± 78 and 312 ± 173 pg/ml, respectively (P < 0.05). Basal uterine venoarterial differences of 6-keto-PGF(1α) were 99 ± 43 pg/ml and increased during 11.5 μg ANG II/min to 295 ± 181 pg/ml (P < 0.05) but not during 1.15 μg/min (64 ± 30 pg/ml). Responses were similar in gravid and nongravid uterine horns. Unilateral uterine prostaglandin inhibition with indomethacin did not alter basal uterine blood flow or systemic responses to ANG II (0.573-11.5 μg/min); however, ipsilateral uterine prostaglandin production fell and uterine vasoconstrictor responses increased (P < 0.05). During ovine pregnancy ANG II increases uterine PGI2 production. PGI2 appears in part to attenuate ANG II-induced uterine vasoconstriction.
Keyword Vascular Reactivity
Cyclooxygenase Inhibition
Uterine Blood Flow
Prostacyclin Production
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 65 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Thu, 26 Aug 2010, 12:59:25 EST