Uteroplacental production of eicosanoids in ovine pregnancy

Magness, R.R., Mitchell, M.D. and Rosenfeld, C.R. (1990) Uteroplacental production of eicosanoids in ovine pregnancy. Prostaglandins, 39 1: 75-88. doi:10.1016/0090-6980(90)90096-E

Author Magness, R.R.
Mitchell, M.D.
Rosenfeld, C.R.
Title Uteroplacental production of eicosanoids in ovine pregnancy
Journal name Prostaglandins   Check publisher's open access policy
ISSN 0090-6980
Publication date 1990-01
Sub-type Article (original research)
DOI 10.1016/0090-6980(90)90096-E
Volume 39
Issue 1
Start page 75
End page 88
Total pages 14
Place of publication Stoneham, Ma., U.S.A.
Publisher Butterworths
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Formatted abstract
Dramatic cardiovascular alterations occur during normal ovine pregnancy which may be associated with increased prostaglandin production, especially of uteroplacental origin. To study this, we examined (Exp 1) the relationships between cardiovascular alterations, e.g., the rise in uterine blood flow and fall in systemic vascular resistance, and arterial concentrations of prostaglandin metabolites (PGEM, PGFM and 6-keto-PGF(1α)) in nonpregnant (n = 4) and pregnant (n = 8) ewes. To determine the potential uteroplacental contribution of these eicosanoids in pregnancy, we also studied (Exp 2) the relationship between uterine blood flow and the uterine venous-arterial concentration differences of PGE2, PGF(2α), PGFM, 6-keto-PGF(1α), and TxB2 in twelve additional late pregnant ewes. Pregnancy was associated with a 37-fold increase in uterine blood flow and a proportionate (27-fold) fall in uterine vascular resistance (p < 0.01). Arterial concentrations of PGEM were similar in nonpregnant and pregnant ewes (316 ± 19 and 245 ± 38 pg/ml), while levels of PGFM and PGI2 metabolite 6-keto-PGF(1α) were elevated 23-fold (31 ± 14 to 708 ± 244 pg/ml) and 14-fold (12 ± 4 to 163 ± 78 pg/ml), respectively (p < 0.01). Higher uterine venous versus uterine arterial concentrations were observed for PGE2 (397 ± 36 and 293 ± 22 pg/ml) and 6-keto-PGF(1α) (269 ± 32 and 204 ± 32 pg/ml), p < 0.05, but not PGF(2α) or TxB2. Although PGFM concentrations appeared to be greater in uterine venous (1197 ± 225 pg/ml) as compared to uterine arterial (738 ± 150 pg/ml) plasma, this did not reach significance (0.05 < p < 0.1). In normal ovine pregnancy arterial levels of PGI2 are increased, which may in part reflect increased uteroplacental production. Moreover the gravid ovine uterus also appears to produce PGE2 and metabolize PGF(2α).
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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Citation counts: TR Web of Science Citation Count  Cited 45 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 26 Aug 2010, 12:59:18 EST