Prostaglandin production by human chorion laeve cells in response to inflammatory mediators

Lundin-Schiller, S. and Mitchell, M.D. (1991) Prostaglandin production by human chorion laeve cells in response to inflammatory mediators. Placenta, 12 4: 353-363. doi:10.1016/0143-4004(91)90343-E


Author Lundin-Schiller, S.
Mitchell, M.D.
Title Prostaglandin production by human chorion laeve cells in response to inflammatory mediators
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
1532-3102
Publication date 1991-07
Sub-type Article (original research)
DOI 10.1016/0143-4004(91)90343-E
Volume 12
Issue 4
Start page 353
End page 363
Total pages 11
Place of publication London, England
Publisher W.B. Saunders
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract Cytokines produced during an intrauterine infection may cause increased prostaglandin production and thus preterm labor. Previously, we have shown that cytokines increase prostaglandin production by human amnion and decidual cells. In the present study we examined the effect of interleukin-1β (IL-1β), tumor necrosis factor (TNF), and endotoxin on prostaglandin production by chorion laeve cells. Upon reaching confluence at day 3 and after 10 days in culture, human chorion laeve cells in primary culture were incubated with each substance. On day 3 of culture the chorion cells demonstrated limited responsiveness to the test agents with a maximum response of less than two times basal production. However, after 10 days the cultures were highly responsive to the test agents with maximum responses of greater than ten times basal production. We conclude that early in culture chorion cells may express fewer functional receptors for the test agents. Alternatively, a subpopulation of chorion cells responsive to cytokines and endotoxin may predominate by day 10 of culture. Chorion laeve, therefore, could contribute to the increased intrauterine prostaglandin production associated with infection-driven preterm labor.
Keyword Preterm Labor
Amniotic-fluid
Bacterial Products
Human Parturition
Fetal Membranes
Primary Culture
Biosynthesis
Infection
Metabolism
Radioimmunoassay
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 12:58:52 EST