Changes in prostaglandin F and 13,14-dihydro-15-keto-prostaglandin F concentrations in amniotic fluid at the onset of and during labour

Keirse, M. J. N. C., Mitchell, M. D. and Turnbull, A. C. (1977) Changes in prostaglandin F and 13,14-dihydro-15-keto-prostaglandin F concentrations in amniotic fluid at the onset of and during labour. British Journal of Obstetrics and Gynaecology, 84 10: 743-746. doi:10.1111/j.1471-0528.1977.tb12484.x


Author Keirse, M. J. N. C.
Mitchell, M. D.
Turnbull, A. C.
Title Changes in prostaglandin F and 13,14-dihydro-15-keto-prostaglandin F concentrations in amniotic fluid at the onset of and during labour
Journal name British Journal of Obstetrics and Gynaecology   Check publisher's open access policy
ISSN 0306-5456
Publication date 1977-10
Sub-type Article (original research)
DOI 10.1111/j.1471-0528.1977.tb12484.x
Volume 84
Issue 10
Start page 743
End page 746
Total pages 4
Place of publication London, England
Publisher Elsevier
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Abstract Concentrations of prostaglandin F (PGF) and its major circulating metabolite 13,14-dihydro-15-keto-PGF (PGFM) have been measured in amniotic fluid during spontaneous labor at term. Levels of both PGF and PGFM were significantly higher during early spontaneous labour, at a cervical dilatation of less than 4 cm, than before the onset of labour. Patients who started labour spontaneously but later required oxytocin therapy for failure to progress in first stage had lower levels of PGF and PGFM than patients who progressed adequately without oxytocin therapy. During spontaneous labour, concentrations of both PGF and PGFM increased significantly with advancing cervical dilatation. These data indicate that the accumulation of prostaglandins in amniotic fluid during labour is not due to decreased metabolism. They furthermore provide the strongest evidence available so far for an increase in intrauterine prostaglandin synthesis during human parturition.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 12:57:36 EST