Regulation of fetal fibronectin production in human amnion cells

Jackson, G. Marc, Edwin, Samuel S., Varner, Michael W., Casal, David and Mitchell, Murray D. (1996) Regulation of fetal fibronectin production in human amnion cells. Journal of the Society for Gynecologic Investigation, 3 2: 85-88. doi:10.1016/1071-5576(95)00050-X


Author Jackson, G. Marc
Edwin, Samuel S.
Varner, Michael W.
Casal, David
Mitchell, Murray D.
Title Regulation of fetal fibronectin production in human amnion cells
Journal name Journal of the Society for Gynecologic Investigation   Check publisher's open access policy
ISSN 1071-5576
Publication date 1996-03
Sub-type Article (original research)
DOI 10.1016/1071-5576(95)00050-X
Volume 3
Issue 2
Start page 85
End page 88
Total pages 4
Place of publication New York, N.Y. U.S.A.
Publisher Elsevier
Language eng
Subject 1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Formatted abstract
Objective:
We evaluated the role of human amnion in the production of fetal fibronectin and assessed the regulation of fetal fibronectin production by inflammatory products and cytokines.

Methods:

Human amnion cells were grown in culture. At confluence, the cells were incubated with and without lipopolysaccharide, interleukin-1β, tumor necrosis factor-α, and interleukin-6. Fetal fibronectin production was measured in the supernatant fluid using an enzyme-linked immunosorbent assay technique.

Results:

Unstimulated amnion cells produced fetal fibronectin, and production was increased by lipopolysaccharide, interleukin-1β, tumor necrosis factor-α, and interleukin-6.

Conclusion:
Human amnion cells in vitro produce fetal fibronectin in substantial quantities. This production is stimulated by inflammatory products and mediators that are considered to be important in the initiation of some cases of preterm labor.
Keyword Fetal Fibronectin
Human Amnion
Preterm Labor
Inflammation
Preterm Delivery
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 12:55:17 EST