Plasma prostaglandins in lung cancer

Hendrick, Alex M., Mitchell, Murray D. and Harris, Adrian L. (1988) Plasma prostaglandins in lung cancer. European Journal of Cancer and Clinical Oncology, 24 6: 1069-1071. doi:10.1016/0277-5379(88)90161-7


Author Hendrick, Alex M.
Mitchell, Murray D.
Harris, Adrian L.
Title Plasma prostaglandins in lung cancer
Journal name European Journal of Cancer and Clinical Oncology   Check publisher's open access policy
ISSN 0277-5379
Publication date 1988-06
Sub-type Article (original research)
DOI 10.1016/0277-5379(88)90161-7
Volume 24
Issue 6
Start page 1069
End page 1071
Total pages 3
Place of publication Oxford ; New York ; Sydney
Publisher Pergamon Press
Language eng
Subject 1103 Clinical Sciences
1112 Oncology and Carcinogenesis
Formatted abstract
Plasma levels of three stable prostaglandin (PG) metabolites were measured in 29 patients with lung cancer. The mean level of 6-keto-PGF1α, the hydrolysis product of prostacyclin was significantly elevated in cancer patients compared to a control group with non-malignant respiratory disorders, although an overlap in values between the groups was seen. Levels correlated inversely with survival and showed a significant fall in 14 patients with tumour regression. The mean level of 11-deoxy-3, 14-dihydro-15-keto-11,16-cyclo-prostaglandin E2 was also significantly elevated in cancer patients, but did not correlate with tumour response. 13,14-Dihydro-15-keto-prostaglandin F2α levels did not differ in lung cancer patients and controls. Contrary to previous reports we could not support a role for the metabolites of PGE2 and PGF2α as tumour markers in lung cancer but plasma 6-keto-PGF1α should be further evaluated in this regard.


Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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Created: Thu, 26 Aug 2010, 12:55:10 EST