Nuclear prostaglandin receptors: role in pregnancy and parturition?

Helliwell, R. J. A., Berry, E. B. E., O'Carroll, S. J. and Mitchell, M. D. (2004) Nuclear prostaglandin receptors: role in pregnancy and parturition?. Prostaglandins Leukotrienes and Essential Fatty Acids, 70 2: 149-165. doi:10.1016/j.plefa.2003.04.005

Author Helliwell, R. J. A.
Berry, E. B. E.
O'Carroll, S. J.
Mitchell, M. D.
Title Nuclear prostaglandin receptors: role in pregnancy and parturition?
Journal name Prostaglandins Leukotrienes and Essential Fatty Acids   Check publisher's open access policy
ISSN 0952-3278
Publication date 2004-02
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.plefa.2003.04.005
Volume 70
Issue 2
Start page 149
End page 165
Total pages 17
Place of publication Edinburgh ; New York
Publisher Churchill Livingstone
Language eng
Subject 0604 Genetics
1114 Paediatrics and Reproductive Medicine
Abstract The key regulatory role of prostanoids [prostaglandins (PGs) and thromboxanes (TXs)] in the maintenance of pregnancy and initiation of parturition has been established [1-3]. However, our understanding of how these events are fine-tuned by the recruitment of specific signaling pathways remains unclear. Whereas, initial thoughts were that PGs were lipophilic and would easily cross cell membranes without specific receptors or transport processes, it has since been realized that PG signaling occurs via specific cell surface G-protein coupled receptors (GPCRs) coupled to classical adenylate cyclase or inositol phosphate signaling pathways. Furthermore, specific PG transporters have been identified and cloned [4-7] adding a further level of complexity to the regulation of paracrine action of these potent bioactive molecules. It is now apparent that PGs also activate nuclear receptors, opening the possibility of novel intracrine signaling mechanisms. The existence of intracrine signaling pathways is further supported by accumulating evidence linking the perinuclear localization of PG synthesizing enzymes with intracellular PG synthesis. This review will focus on the evidence for a role of nuclear actions of PGs in the regulation of pregnancy and parturition. © 2003 Elsevier Ltd. All rights reserved.
Keyword Prostaglandin
Nuclear Receptor
Proliferator-activated Receptors
Hormone-related Protein
Gamma/RXR-Alpha Heterodimers
Lipoxygenase Metabolite Formation
Cytosolic Phospholipase A(2)
Arachidonic-acid Metabolism
Vascular Endothelial-cells
Jeg3 Choriocarcinoma Cells
AT(1) Angioteison Receptor
Human Gestational Tissue
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Centre for Clinical Research Publications
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Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 26 Aug 2010, 12:54:26 EST